This section is from the book "Materia Medica Pharmacy, Pharmacology And Therapeutics", by W. Hale White. Also available from Amazon: Materia Medica Pharmacy, Pharmacology And Therapeutics..
(Not official.)-CCl3CH.OH.Conh2 =191.95. Synonym. - Chloralamide.
By the combination of Chloral and Formamide. CCl3Cho+ Chonh2=CCl3CH.OH.Conh2.
Shining colorless crystals, without odor and of a slightly bitter taste. Solubility. - Slowly, in about 20 parts of water, in 1.5 parts of Alcohol, and in weak acid solutions. It should not be heated over 1400 F.; 6o° C., or mixed with alkalies, for, in either case, it decomposes into Chloral.
Dose, 10 to 30 gr.; .60 to 2.00 gm.
Chloralamide is an excellent hypnotic, producing calm, refreshing sleep without any bad after-effects. Frequent use does not necessitate an increased dose, nor, as far as known, is any habit contracted. It does not relieve pain, but is equally serviceable for all varieties of insomnia, unless due to pain. If possible it should not be given as a powder, for it is then so very slowly absorbed that probably some of it is decomposed in the intestines or stomach; very rarely, when powdered chloralamide has been administered in the evening, the patient has not slept during the night, but has slept all the next day, because the drug has been so slowly absorbed. The best way to give it is to dissolve it in a little alcohol. The patient may be told to dissolve 20 gr.; 1.20 gm. or more, in sufficient brandy, to add water not above 1300 F.; 54.40 C, and drink it before going to bed. Some specimens are very insoluble, and must be suspended. It is said that 10 minims .60 c.c of aromatic sulphuric acid added to 1 fl. oz.; 30 c.c of water will dissolve 30 gr.; 2 gm. of chloralamide, but this is not always true. It acts if given as an enema. Fifteen grains 1.00 gm. of potassium bromide and chloralamide, flavored with tincture of orange peel and chloroform water has been strongly recommended for insomnia and for sea-sickness. This mixture resembles a proprietary preparation called Chlorobrom.