The leaflets of Pilocarpus Selloanus Engler (Rio Janeiro Jaborandi), and of Pilocarpus Jaborandi Holmes (Pernambuco Jaborandi), (nat. ord. Putaceae).


Brazil, near Pernambuco.


About 10 to 15 cm. long, and 4 to 6 cm. broad, short-stalked, oval or ovate-oblong, entire and slightly revolute at the margin, obtuse and emarginate, unequal at the base; dull green, coriaceous, pellucid punctate, mostly smooth; when bruised, slightly aromatic; taste somewhat bitter and pungent.


Leaves of species of Piper, not oval-oblong.


The chief constituents are - (1) A liquid, colorless, alkaloid, Pilocarpine, C11H16N2O2, 1/4 to 1 per cent. (2) Jaborine, C22H32N4O4, an alkaloid resembling in its physiological action Atropine, and therefore antagonistic to Pilocarpine. (3) Pilocarpidine, C10H14N2O2, a decomposition product whose action is weaker than Pilocarpine. (4) A volatile oil chiefly Pilocarpene, C10H16. (5) A peculiar acid. These active principles are soluble in Alcohol, but only imperfectly so in water.

Dose, 5 to 60 gr.; .30 to 4.00 gm.


Extractum Pilocarpi Fluidum. Fluid Extract Of Pilocarpus

By maceration and percolation with Diluted Alcohol and evaporation. Dose, 5 to 60 m.; .30 to 4.00 C.C.

Pilocarpinae Hydrochloras. Pilocarpine Hydrochlorate

C11H16N2O2HCl=243.98. The hydrochlorate of an Alkaloid obtained from Pilocarpus.


Obtained by exhausting Pilocarpus with Alcohol acidulated with Hydrochloric Acid, distilladon and evaporation. The filtrate is treated with a slight excess of Ammonia, and a large quantity of Chloroform. The solution is agitated with water, to which Hydrochloric Acid is added to neu-tralizadon. The Hydrochlorate is obtained on evaporation in crystals which are purified by re-crystallization.


Small, white crystals, odorless, and having a faintly bitter taste; deliquescent on exposure to damp air.


Very soluble in water and in Alcohol; almost insoluble in Ether or Chloroform.

Dose, 1/8 to 1/3 gr.; .008 to .02 gm.