(Not official.) - Synonym. - Tetramethyl-thionin chloride. C16N18N3SCl=318.90.


By treating dimethylparaphenylenediamine (Nh2c6h4n(Ch3)2) in an acid solution with Hydrogen Sulphide and Ferric Chloride.


In small, blue, scaly crystals, with a copper-bronze tinge. Solubility. - Readily in water.

Dose, 1 to 5 gr.; .06 to .30 gm.

Action and Uses of Methylene Blue

Methylene blue (not to be confounded with methyl blue) has been introduced into medicine as antiseptic. It has been used for rheumatism of the joints and muscles. Lately it has been given for intermittent fevers, but the reports show that it possesses no advantage over quinine excepting that it is tasteless and may be substituted for it if it cannot be taken or it has been unsuccessfully used. Recent reports indicate that even when given internally it causes gonococci to rapidly disappear from the urine in specific urethritis. As to its effects upon inoperable neoplasms when injected into them clinical reports differ widely. It imparts a blue color to nerve substance and a like color to the urine. It may produce irritation at the neck of the bladder, which about 30 gr.; 2 gm. of powdered nutmeg is said to relieve. It has been used as an analgesic in neuralgia, migraine, sciatica, and rheumatism.