This section is from the book "Materia Medica Pharmacy, Pharmacology And Therapeutics", by W. Hale White. Also available from Amazon: Materia Medica Pharmacy, Pharmacology And Therapeutics..
C4H10N2=85.9. Synonyms. - Piperazi-dine. Diethylenediamine. Dispermine.
(This drug is antiseptic only so far as its clearing the urine of pathological products prevents decomposition. It is placed here for convenience.)
By the action of Ammonia on Ethylene Chloride. The mixture of bases is fractionated, and from the fraction boiling between 266o F.J 130o C, and 356o F.; 180o C, Piperazine separates on cooling.
Dose, 8 to 15 gr.; .50 to 1.00 gm.
Piperazine is believed to increase slightly the amount of urea in the urine, while the uric acid co-efficient is diminished. The testimony as to its diuretic action is conflicting, but the weight of clinical evidence is in favor of its being a reliable diuretic. In ordinary doses it does not appear to have any influence upon the nervous, circulatory or respiratory systems; nor does it irritate the gastro-intestinal or the genito-urinary tract. There is much clinical testimony as to the value of this drug in gout, goutiness (uricacidaemia) and rheumatism. It is here given in water containing carbon dioxide. It is so highly hygroscopic that it cannot be administered as pill or powder.