A. Purpuric spots, O'Reilly, 153, Jan. '54, 7; Abbe, 110, 4: 131; 205; (H.G.P.).

Petechial rash on legs, Ringer, 162, Mar. '72, 129.

Vesicles, Hyde, 110, 5: 333.

Vesico-pustular eruption with erythematous blush, Finny, 116, 2/79, 291.

Papules becoming vesicular, Duckworth, 142, 2/78, 432.

Papules and small pustules, Johnson, 116, 1/59, GO; Flagg, 118, '48.

Acne, 4, 165; 203.

Hard papules and vesicles, the fluid of which contained iodine, Duckworth, 172, '79, 39.

Bullae, O'Reilly, 153, Jan. '54; Bumstead, 102, July, '71; Hyde, 110, 5: 33; 205.

Erysipelas, Curgenven, 137, 2/67, 88.

Erythema, scales, papules, pustules, 205.

The loose tissues about the orbit become swollen, reddened, and edematous, and occasionally a peculiar rash appears upon the skin of the face, at first noticed around the eyes, after which it attacks the nose and the neighboring parts, and then the chin. The nose is sometimes reddened, especially at the tip, and is rather swollen. The rash does not always present the same appearance. It is often very much like acne, and is always hard and shotty, and indurated: but the papules may be broad and large, and covered with what looks like a half-developed vesicle or pustule.

In some persons the iodides produce a petechial rash, almost always affecting the leg exclusively, rarely extending above the knee, and still more rarely to the trunk and upper extremities. It may at first take several days to produce this rash, but when the spots have disappeared one dose of five grains may in three hours suffice to reproduce it, 5, 76-7.

Eruption resembling hydros. It is sudden and symmetrical, and prefers the face and forearms. Vesicles and small bulla;, from the size of a shot to that of a pea, or even to that of half a small cherry, and usually surrounded by an erythematous base, and sometimes inflammatory swelling of the skin. In the earliest stages the papules resemble those of small-pox. The vesications become larger, lifting up a very delicate layer of epidermis, which presents no central depression. Their contents become gray and opaque, but not distinctly purulent. Although there is no umbilicus, vet a peculiar appearance is sometimes assumed by the vesication spreading at its margin and sinking at its centre, the patch then becoming sometimes as large as a shilling. Hutchinson, 172,

Microscopical appearances.