The following are some of the special applications of the remedy.

In pseudomembranous inflammation of the mouth and fauces, it is almost a specific, so far as the local disease is concerned. Even in pseudomembranous croup, it has been employed with success, by the introduction of a strong solution through the lima glottidis into the interior of the larynx; and would probably prove more frequently effectual, were it not for the depth into the bronchial tubes to which the disease too often penetrates. in the false membrane which characterizes the anginose cases of scarlet fever, it should always be employed, especially if any disposition is evinced to spread towards the larynx. But, I would repeat, whenever nitrate of silver can be brought effectively into operation in pseudomembranous inflammation, wherever it may exist, so far as this affection is concerned, it may be expected to exercise a favourable influence.

In chronic stomatitis, angina, and laryngitis, particularly of the follicular character, nitrate of silver, in connection with such constitutional measures as the case may require, is the most effective remedy. A strong solution should be applied every other day, every day, or even more frequently, when the urgency of the case calls for it, and the membrane is not too sensitive to bear it.

In the commencing stage of acute angina, or tonsillitis, it will sometimes arrest the inflammation, especially in conjunction with general antiphlogistic measures; and, in chronic enlargement of the tonsils, it is probably the most efficient measure next to excision.

Chronic inflammation of the nostrils and external meatus of the ear yield perhaps more readily, on the whole, to this than any other local remedy. it is to the suppurative states of these affections that it is best adapted. Ozaena will, I believe, often yield to it, if properly applied to the whole diseased tissue. But, in both these affections, one great objection is the discoloration of the skin produced by it, which almost necessitates confinement on the part Of the patient, unless the application is conducted with the greatest care to avoid contact of the solution with the cuticle. The proper plan, in these cases, is to begin with a weak solution of the nitrate, say one or two grains to the fluidounce, and gradually increase, as the surfaces respectively are found to bear it, to five or ten grains or more.

Certain cases of ophthalmia are often much benefited by nitrate of silver. I have already spoken of ulcers on the cornea and conjunctiva, in which it is an almost sovereign remedy. in the purulent ophthalmia of children, a strong solution has been employed successfully; and in the thickening of the palpebral conjunctiva, which sometimes maintains a chronic inflammation of the eye, it is perhaps the most efficient application. it may be used in ordinary chronic conjunctivitis; but milder remedies will generally answer.

Psorophthalmia, according to my experience, yields to it more readily than to any other application.

In inflammation of the mucous membranes of the rectum, urethra, and vagina, it is not less effective than in those already mentioned, and it has even been used in mucous inflammation of the bladder. To its use in dysentery I have already alluded. in leucorrhoea, it is often very effectively applied to the os uteri and vagina; and in recent gonorrhoea, both in the male and female, it is asserted sometimes to prove effectual; but it has also sometimes greatly aggravated the affection, which should be treated by milder measures. in chronic gonorrhoea or gleet, it is clearly indicated.

Cutaneous inflammations are scarcely less benefited than those of the mucous membrane. Mr. Higginbottom strongly recommended it in erysipelas, and it will undoubtedly often remove the disease; but it sometimes also fails, is disagreeable from the discoloration it produces, and, on the whole, is perhaps less appropriate than some other measures of suppression. in relation, however, to erysipelas, my own impression is that, as it is the result frequently of a constitutional disorder, it is better, as a general rule, that it be allowed to run its course, under gentle demulcent applications, with the use of suitable constitutional measures; care being taken to prevent its progress, when disposed to extend far, and into dangerous positions. For the latter purpose, a solution of the nitrate has been recommended; a broad band being drawn with it around the erysipelatous surface, embracing the outer border of the inflamed and an equal portion of the sound skin, to the breadth of about two inches. But here also the remedy occasionally fails, and iodine, or perhaps even an ordinary blister, is generally to be preferred.

In various cutaneous eruptions, especially of a limited character, the nitrate of silver is often very useful. if applied to each one of the variolous pocks, on the first or second day, it will generally render them abortive, and thus prevent unseemly scars and pitting of the face. in porrigo or favus, similarly applied to each of the eruptions, it will generally completely arrest that obstinate disease, probably by destroying the characteristic cryptogamic growth. in the clusters of eczema and herpes, and the pustules of ecthyma, it is often effectual. But the discoloration of the cuticle produced by it is a strong objection, in all eruptions covering extensive portions of the surface, in which, therefore, other remedies are usually preferred. in excoriations, as of the nipples, and in cases of intertrigo, the solid nitrate is sometimes usefully employed.

Subcutaneous inflammations are sometimes benefited by the remedy; as paronychia, furuncles, phlegmons, inflamed absorbent glands, etc.

Application. For its caustic effect, the salt may be applied in substance, or strong solution. in the first method, it will be found most convenient to use the pointed stick. The caustic solution may be made of the strength of from one to three drachms to the fluidounce of water; or even a saturated solution may be used, if deemed advisable. it is usually best applied by means of a camel's-hair pencil; and care should generally be taken not to extend its application beyond the diseased surface. For stimulant and alterative purposes, the solution employed may vary in strength, from one to forty grains to the fluidounce. When applied to sensitive membranes, as those of the eye, ear, nostrils, urethra, and bladder, a weak solution should be used at first, say from half a grain to three grains to the fluidounce, and increased in strength as the parts may be found to bear it. For injection into fistulous sores, or simply as a stimulant to indolent ulcers, the proportion may be from three to ten grains to the fluidounce. When applied to acute inflammations, its strength should be considerable, say from ten to twenty, forty, or even sixty grains to the fluidounce, as the weak solutions only irritate, and do not subvert the disease. in erysipelas, Mr. Higginbottom used the pointed stick, or a solution nearly saturated. To prevent pitting in small-pox, in the confluent cases, a strong solution should be used, containing a drachm to the fluidounce, which should be applied over the whole surface of the face on the second or third day of the eruption. (Med. Times and Gaz., Jan. 1857, p. 96.) A somewhat weaker solution is used with great advantage, by Dr. John Wiltbank, of Philadelphia, in scalds and burns. (Boston Med. and Surg. Journ., liv. 118.) in affections of the mouth, fauces, and laryngeal mucous membrane, the solution should generally be strong. The menstruum should be pure distilled water, or rose-water, which is also distilled. Any saline matter present would probably decompose the nitrate.