This section is from the book "Research In Physiopathology As Basis Of Guided Chemotherapy With Special Application To Cancer", by Emanuel Revici. Also available from amazon: Research In Physiopathology
An interesting aspect of the concept presented above is the influence of homotropic and heterotropic forces upon the motion of particles within the organizational framework. At random mobility must be considered to be an attribute of entities free of any constraint, and thus corresponding to a homotropic state. Any change toward constraint, leading to a degree of immobilization, must be considered a heterotropic effect. The systematized mobility produced by quantum forces, which appears to prevent annihilation of opposing charges, accounts for the relative immobilization. While mobility itself is an homotropic attribute, its systematization is heterotropic.
The correlation of mobility with homotropy, and of fixation with heterotropy, appears basic. The process of uniformization which corresponds to homotropy appears to be possible only in the presence of a maximum of free mobility. The heterotropic systematization of movement can be seen at various levels of organization. Electrons in movement in the atom differ from electrons in movement in the environment through a systematization of their mobility, as they are constrained to follow definite patterns. The relative fixation of certain electrons—for instance, shared electrons—following the fulfillment of quantum forces also marks a further heterotropic influence. This also applies to radicals such as the carboxyl.
In the formation of the movement of electrons, in itself, is homotropic, while the limitation of movement between the two oxygens is an heterotropic effect. With the electron fixed in one position, bound to only one oxygen, a further step in immobilization is achieved and represents a heterotropic factor. In more complex molecules, such as unsaturated fatty acids, for example, the tendency of the electrons to wander is related to homotropy, while their restriction to the molecule or even to certain areas of the molecule represents an heterotropic effect. This also applies to micelles, where the water molecules and impurities have a certain degree of mobility. This mobility must be considered to be a vestige of the movement of free water molecules, with a high mobility considered as a homo polar effect at this level. The retention of water or other molecules in the micelle may be considered as a heterotropic effect. And their further fixation, as in the activated micelle, is a further heterotropic effect.
Organization, which results from the alternate operation of electrostatic coulombian homotropic and organizational heterotropic tendencies, leads to the realization not merely of stable configurations but, more significandy, to entities capable of reactivity, and consequently able to respond actively to the various changes of the environment. The fact that fulfillment of quantum forces causes appearance of new electrostatic forces, which will be further neutralized, leads to the progress of organization to ever higher levels.
At each step of organization, however, another characteristic can be recognized. It results, in part, from the fact that progress toward higher entities is accomplished by an increase in complexity rather than only in size. The increase in the positive charge of nuclei in atoms, for instance, brings about a parallel increase in the number of surrounding electrons, but this goes on only up to a certain point. Actually, the size of the atoms is limited by the size of the nucleus which, in turn, is limited by the quantum forces able to insure stability for the nucleus. Nuclei become unstable when they contain too many protons.