This section is from the book "Research In Physiopathology As Basis Of Guided Chemotherapy With Special Application To Cancer", by Emanuel Revici. Also available from amazon: Research In Physiopathology
From the beginning of this study, manifestations, clinical and analytical, present in a variety of abnormal conditions, have appeared to conform to the basic physiopathological concepts presented above. In these varied conditions, however, more often than in advanced cancer, some analyses have shown no abnormal patterns while others have shown them so constantly as to indicate that certain anomalies, often limited to specific levels of organization, are of great importance. In spite of individual variations, some of the conditions studied have shown patterns and interrelationships of patterns that provide characteristic analytic pictures which will be analyzed in further publications. Furthermore, some of these patterns appear to be so strongly related to a given condition that our attention was directed to the idea of a fundamental relationship between the processes related to the patterns and the pathogenesis of the condition itself. The following examples illustrate this.
An impressive relationship was found between the presence of peroxides in urine and schizophrenia. We mentioned previously the reaction which we devised for detection of these substances in urine. This reaction would indicate the existence in the body of abnormal processes in oxygen metabolism, leading to the appearance of peroxides in the urine. We saw that these processes ultimately could be related to an abnormal intervention of fatty acids, corresponding to the oxygen phase of offbalance D.
Daily urinary analytical patterns were studied in a group of 27 advanced schizophrenics over a period of three years. Over 27,000 urinary samples were examined and more than 135,000 tests performed. Oxidizing substances were found in 87% of these samples. This appears to be highly significant when compared with only 2% positive values in subjects considered clinically normal, and 4% in cancerous cases submitted to various treatments. Not a single negative analysis was seen in some of these schizophrenics during the three years of daily testing. This suggested that the metabolic abnormality, characterized by the appearance of peroxides, might play an important pathogenic role in this disease. (221)
Another example of a pattern revealing characteristic pathogenic processes was seen in geriatric cases. Old people often have a manifest abnormality in urinary S. T. Figure 261, page 648 shows the values encountered in old people compared to those in subjects of mixed ages. The high surface tension in the aged group is related to predominance of sterols at the systemic level. Such predominance is also found at the organic level of the skin, for instance. A clinical test, wheal resorption time, indicated abnormal values for almost all the aged subjects studied, as shown in Figure 68. These data, integrated into the general concept of complex conditions, led us to the pathogenic concept of old age presented above.
The urinary chloride retention index in subjects in a state of shock consistently shows such exceptionally high values that our attention was directed to the study of the role of abnormal metabolism of chlorides in the pathogenesis of the condition itself. This view has been confirmed by further research, as mentioned previously.
The study of the different conditions in terms of fundamental pathogenic concepts has had other consequences. It has established clearer relationships between these conditions and cancer than previously recognized. In fact, many of the data first obtained in the studies of these other conditions have been applied specifically to cancer.
One example is shock. Occurring in the terminal stage and usually leading to death, shock often has been considered to be one of the "complications" of advanced cancer. Under the concept of organized complex condition, however, it could be seen that, in cancer, shock is related to off balance type D of the terminal systemic phase. The study of shock has greatly contributed to the knowledge of this offbalance in cancer.
The therapeutic approach, in which the choice of agents and the doses used are determined by the different patterns present, has been useful in many noncancerous conditions in which the anomaly apparently is limited to one level of organization or even to a special group of entities. As examples here, we will discuss conditions in which manifestations are produced by an acid base tissular abnormality.