Acidum Picricum. Yellow crystals, odorless, and intensely bitter. It is soluble in alcohol, ether, and chloroform, and slightly so in water. It is poisonous, acting as an irritating depressant, causing profuse diarrhea, convulsions, and collapse. The antidote is albumin. It is incompatible with all oxidizable substances, albumin, alkaloids, etc., and with sulphur and phosphorus is explosive. Never apply to the skin either in substance or in ointment, as toxic results may follow. The maximum dose is 5 grains, and it may be administered safely in doses. of I grain in trichiniasis, but its general use internally as an antiperiodic and antiseptic cannot be commended in view of its toxicity. Externally, it may be applied to burns of not very great superficial area, using 0 to I % hydro-alcoholic solution for only a few minutes, then covering with cotton. Do not renew application more frequently than once in three days. It controls pain and rapidly promotes healing, but is an agent to be used with the greatest of care and not at all in extensive or deep burns. In small doses it has been employed in degenerative changes in the spinal cord, but the present writer regards it very unfavorably.