Lactucarium, Lactuca Virosa. This U. S. P. substance is apt to be unreliable, but the tincture (50%), when made before changes occur in the drug, is a fairly dependable remedy in doses of 10 to 60 I. Squibb makes an excellent fluidextract of lettuce. It is a nerve sedative and mild hypnotic quite useful in functional disturbances. In irritable coughs it finds quite a field of usefulness. With some women it acts as a galactagogue.