Caffeine is a xanthine compound derived from the dried seeds of Coffea arabica (Fam. Rubiacecc), a native of Arabia. It is also obtained from the leaves of Thea sinensis (Fam. Ternstraemiaceac); an Asiatic shrub. It also occurs in other plants, and may be prepared synthetically.

By treating Caffeine with citric acid in hot water there results a substance of loose chemical structure known as Citrated Caffeine.

Properties:

Caffeine:

Citrated Caffeine:

Appearance.......................................................................................

Appearance........................._...............................................................

Color .........................................................................................................

Color .........................................................................................................

Odor .........................................................................................................

Odor .........................................................................................................

Taste........................................................................................................

Taste .........................................................................................................

Solubility:

Solubility:

4 H2O...............................................................................................

4 H2O................................................................................................

8 H2O ................................................................................................

8 H2O ................................................................................................

25 H2O.............................................................................................

25 H2O.............................................................................................

50 H2O.............................................................................................

50 H2O.............................................................................................

Hot H2O .......................................................................................

Hot H2O .......................................................................................

C2H5OH ..........................................................................................

C2H5OH..........................................................................................

Caffeine is a stimulant to respiration, kidney activity, and cerebrospinal reflexes. It also seems to improve vascular conditions when the circulatory system is functionally enfeebled. Dose of Caffeina, 0.15 Gm.; of Caffeina Citrata, 0.3 Gm.

Other Official Preparations.

Caffeina Citrata Effervescens. Dose, 4 Gm.

Caffeinae Sodio-Benzoas. Dose, by mouth, 0.3 Gm.; hypodermic, 0.2 Gm.

This latter substance is a mixture of about 46% anhydrous caffeine and about 54% sodium benzoate.

Two other xanthin products are the official Theophyllina, found in small amounts in tea leaves, and also made synthetically; and Theobromine, derived from Theobroma Cacao, with an official salt, Theobrominae Sodio-Salicylas. These two substances are both dimethylxanthine. They possess but little advantage over the trimethylxanthine Caffeine, though a more marked diuretic action, with no cerebral effect, is claimed for theobromine.

Stramonium Plants In Fruit (Datura Stramonium).

By permission of Burroughs Wellcome Co.

Stramonium Plants In Fruit (Datura Stramonium).