Barium chloride was introduced at the end of last century as effective in scrofulous and syphilitic dyscrasiae, in gonorrhoea, white swelling, etc. (Crawford, 1780). Lisfranc and Torget used it in such cases and in glandular tumors, and reported much advantage from it; the former began with 1/8 gr. every hour, and increased the dose to much larger quantities than we should consider safe (40 gr.). In a child, many glandular tumors subsided under a month's treatment, but frictions with iodide of potassium were used at the same time (American Journal, 1838, No. 45, Bulletin de Therapeutique, 1840). Mr. R. Phillips recommended barium chloride as superior to iodine in many cases marked by pallor, languid circulation, and irritable mucous membranes ("On Scrofula," 1846), and Mr. Balman used it in chlorotic and cachectic states generally (Medical Times, ii., 1851). In amenorrhoea he gave 1/2 to 1. gr. doses with per-chloride of iron. Many cases of successful treatment of scrofulous joint-disease, of ophthalmia, and of enlarged glands by barium chloride (1/12 gr. doses), were recorded some years ago (Ranking, 1846).