This section is from the book "Essentials Of Materia Medica And Therapeutics", by Alfred Baring Garrod. Also available from Amazon: The Essentials Of Materia Medica And Therapeutics.
Prep. A mixture of the freshly precipitated peroxide and protoxide of iron (prepared by precipitating a solution of the persulphate and protosulphate of iron by means of soda) is dissolved in a solution of citric acid, and to this is added quinia (prepared by dissolving sulphate of quinia by the aid of a little hydrochloric acid in water, removing the sulphuric acid by means of chloride of barium, and precipitating the quinia by ammonia), and the liquid digested on a water bath till the alkaloid is dissolved. It is then evaporated in thin layers on porcelain or glass plates, in the manner directed for the ammonio-citrate.
Prop. & Comp. It occurs in thin scales of a golden-yellow colour, deliquescent, entirely soluble in cold water. The solution is slightly acid, and is precipitated reddish-brown by solution of soda, white by solution of ammonia, blue by the ferrocyanide and by the ferrideyanide of potassium, and greyish black by tannic acid.
Taste bitter and chalybeate. When completely burned with exposure to air, it leaves a residue which yields nothing to water (peroxide of iron). Fifty grains dissolved in 1 fluid ounce of water, and treated with a slight excess of ammonia, yield a precipitate of quinia, weighing when dried 8 grains. The precipitate is entirely soluble in ether, when burned leaves no residue, and when dissolved in a dilute acid and purified with a little animal charcoal yields a solution which turns the plane of polarisation strongly to the left. This test determines the amount, nature, and purity of the alkaloid. The salt contains citrate of the proto- and peroxides of iron united with citrate of quinia, and the amount of the alkaloid estimated as citrate of quinia is 25 per cent.
Therapeutics. This salt possesses the combined properties of both iron and quinine.
Dose. 5 gr. to 20 gr.
Adulterations. Deficiency of quinia, and substitution of cincho-nia, etc, indicated by above tests.
 
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