In following the directions for making elixirs by this work, it will be observed that we refer to alkaloid cinchonidine, and alkaloid quinine, as well as alkaloid cinchonine. The last is in general use, but the others must often be prepared extemporaneously. In reviewing the processes which have been heretofore recommended, we find consid-erable trouble in manipulation. The plan of our Pharmacopoeia (1870) is that of dissolving the sulphate of the alkaloid in water, by means of sulphuric acid, and then precipitating with ammonia water, after which the precipitated alkaloid is washed with water. In following this process we find a very bulky, amorphous precipitate, and which requires a large amount of water before it can be thoroughly freed from ammonium sulphate. Again, when we attempt to dry this precipitate, if the weather is moderately warm, it runs together, agglutinates, and finally forms a transparent, horn-like mass which adheres closely to the paper. In order to overcome these troubles, the writer has devised the following process, which yields an alkaloid which answers every purpose required by the class of preparations under consideration: