Between the first cold of infancy and death from cancer in middle life, there are intermediate complexes and symptoms galore--colds, coughs, sore throats, constipation, diarrhea, headache, tired feeling, grouchiness, apprehension, restlessness, sleeplessness, bad breath, coated tongue, languor, a sense of weariness over the eyes, depression of the whole body towards noon, commonly met with a stimulant, intolerable ennui, other aches and pains, and many so-called acute diseases, all of which are but crises in toxemia.

Catarrhal inflammation--a cold, gastritis, inflammation of the tonsils, etc.--are but crises in toxemia. Organic change is an ending resulting from repeated toxemic crises, causing functional irritation, inflammation, enlargement, enduration and degeneration, which may be tumor, cancer, tuberculosis and death from septicemia. Repeated for months and years, catarrhal inflammations end in chronic catarrh of the nasal passages, ulceration, hay fever and other so-called nasal diseases. Tonsillitis ends in chronic thickening and enlargement. Repeated crises in the stomach end in ulceration and cancer. Frequent diarrhea with intermittent constipation ends in chronic colitis, ulcerative colitis, polyps and cancer.

The first deviation from health is a gradually developing enervation resulting from enervating mental and physical habits. So long as enervation and checked secretion and excretion persist, there is a general inability of the organs of the body to function normally. The toxemic state slowly devitalizes the tissues over a period of years, resulting in delayed healing and degeneration of injured or devitalized parts. The varying symptom-complexes, starting with enervation and progressing to toxemia and impaired nutrition, with a gradual deterioration of the entire system, and ending finally in ulceration, enduration and fungation (cancer) is a long, drawn-out pathological evolution with a continuous degeneration of tissue. "The sum of the symptoms," wrote Tilden, "of all so-called diseases make up the symptomatology of toxemia.." Instead of these crises being the cause of the succeeding pathological states, they are constituents of the total pathology. One pathology is no more the cause of another pathology than speaking and answering cause conversation. They are parts of the course of pathology, not its cause.

The principle of unity and continuity has not been applied to pathological evolutions sufficiently long and too few men have devoted themselves to it for us to have traced out all the gradations of development, from its first indistinct and imperceptible rudiments, through all the multiplicity of developments to its final endings in pathology of such magnitude that life is no longer possible. Arising, as it were, out of enervation and toxemia as the pathological substratum, by infinitely minute degrees, stage after stage of pathology evolves and thus, onward and downward, are the lowest stages of pathology--the end points that result in death--arrived at. The organism gradually deteriorates under this continued and mounting toxic saturation and various organs show change.

It is not difficult to trace almost imperceptible gradations of pathology in the bodies of the sick until we arrive at the most advanced stages of pathological evolution. If, in our present state of knowledge, we are compelled to leap over many intermediate stages in pathological evolution and progress from one stage to another by observing largely the more distinct steps, the future will fill in the gaps and provide our successors with fuller knowledge than we now possess.

Evolutionary pathology, which belongs to the Hygienic System, rests squarely on the fact of a breach of the laws of being that govern the behavior of organisms in their relations to each other and to their environment. It involves the mal-observance of the fundamental laws that underlie the world of life and it can be shown in a thousand ways that disobedience to the laws of organic existence produces evil results. Violated law leads, in the first place, to an abnormal metabolism and thence by self-poisoning, to weakness, decline and premature death. Along the way there is the evolution of monstrosities and cancer.

Pathological developments in each individual case are in line with tendencies or diatheses. It is probable that the pathological tendencies of the individual always arise out of actual defects or disharmonies within the individual. Every deviation from normal relations in living structure is defect and deformity; in the vital functions it is disease. However much a so-called disease in one person may have in common with the "same" disease in another individual, because of a common source of disease and a common organ-functional complex, it is different by as much as the organisms differ. This is not to say, however, that there are no other factors that add to the differences between the two "diseases." Unfortunately, those hereditary weaknesses that constitute pre-dispositions are not to be dreaded merely as contributing factors in the production of disease, but also because of the obstacles which they throw in the way of permanent recovery.

We need only to know the conditions under which organic integration flourishes in order to understand the conditions under which integration languishes and is transformed into one or another form of disintegration. For want of nothing but knowledge of the right ways and the proper opportunity for development, present generations are not half developed, either in body or in mind; the young are marred and scarred saplings, whose later years will evince distortions of body and mind resulting from the injurious care and treatment of the earlier years.

Many things in the daily life of man will precipitate a crisis in the profoundly enervated and toxemic. If they are also infected with intestinal putrescence, the crisis may be a very severe one. Variegated as the symptom-complexes called diseases appear, variegated as the symptomatology of even one of these complexes may be, they all rest on the solid foundation of toxemia which has resulted from checked excretion growing out of enervation.

When any portion of the mucous membrane of the body is requisitioned to do vicarious duty for the normal organs of elimination, which have had their functions lowered by enervation, we have a so-called catarrhal disease. When, by practicing enervating habits of body and mind, the individual has established chronic catarrh of the intestinal, respiratory and genito-urinary tracts, he is in line for the development of a wide variety of symptom complexes, ranging from a cold through tonsillitis, pharyngitis, laryngitis and bronchitis to hay fever, asthma, polyps, pneumonia, bronchiectasis and tuberculosis, from gastritis through constipation and diarrhea, to simple colitis, ulcerative colitis, gastric ulcer, intestinal polyps and cancer; from metritis and leukorrhea or cystitis, through ovaritis, cervicitis, to uterine polyps and cancer; from simple urethritis through cystitis, nephritis, ulcers of the womb and bladder, to stones in the kidneys and cancer; from cholecystitis to simple hepatitis; through gall stones and jaundice to cancer of the gall bladder or liver. All chronic diseases evolve out of frequently repeated crises in toxemia--this is to say, out of acute diseases. Enervating habits, to which are added habitual overeating, wrong eating, drug habits and drug treatments, lead on and on, step by step, from simple toxemic crises to the most formidable diseases of the nosology. Unless the enervating habits are corrected the enervation increases, toxemia grows greater and a slow but progressive degeneration of the mucous membranes, blood vessels, heart, lymph and other organs of the body takes place.