On dissection, the brain, the medulla oblongata, and all the muscles, are said to be drier than usual: the membranes extenuated; the pericardium dry; the blood coagulates slowly, if at all; and putrefaction soon comes on. The fat appears completely wasted; the gall bladder full of greenish bile; and the stomach covered with a glary matter of a brown colour, and its villous coat livid. The liver, contiguous to the stomach, is livid, and the trachea and oesophagus inflamed.

The poison of rabid animals is, like that of the small pox, secondary in its operation. It lies concealed till, perhaps, by an assimilatory process, its quantity is increased, or from the he, at of the body it becomes more active. It is sufficiently certain, that, if the part is extirpated soon after the bite, the patient is safe: it is highly-probable that the same operation at the first commencement of the inflammation would be equally advantageous. When absorbed, like other poisons it is carried to some excretory; and that which from chemical affinity or some other cause is preferred, we find to be the salivary and the mucous glands of the fauces. Previous, however, to this determination, it shows deleterious effects on the nervous system by the melancholy, the increased sensibility, and the affection of the precordia, which precede. These are the natural and genuine effects of the poison, which prove sometimes fatal without any others following. Mead.

When the poison is determined to the excretories, it shows a powerful and active stimulus. Inflammation, which is the consequence, in the mouth and fauces, seems to occasion the difficulty of swallowing. The increased sensibility, however has some influence; for if the patient does not see the fluid, or it is not given in a shining vessel, the convulsions are much less violent. The sensation of cold water to the inflamed fauces contributes to the effect. In all these respects, solids will be less offensive than fluids; and in general they are swallowed by a less effort.

The disease in dogs is not owing to heat, but is probably produced by their confinement in kennels. In man the disease is exclusively owing to the poison introduced by the wound; but its action is said to be accelerated, probably increased, by fear, grief, or any of the depressing passions. The prognosis is always unfavourable.

If, in a disease where remedies are so uncertain, we were to draw any prophylactic indications, they would be, first, to prevent the poison from acting, though it exists in the body; secondly, to evacuate it by the most speedy methods.

This disease is peculiarly rare. Some practitioners of the most extensive experience have never seen it; and some have boldly denied its existence. In general, very few of the dogs reputed to be mad are really so; and but a small proportion of those bit by a dog, really mad, receive the infection, as the parts are usually defended by the clothes, and the teeth of the animal are consequently wiped clean before the wound is inflicted. This circumstance has given a delusive credit to many trifling preparations employed as prophylactics. None are to be trusted except excision; but it is necessary to state, according to the indications laid down, what has been proposed.

We have already remarked, that nature is able to evacuate morbid poisons, if the animal power is supported, or at least no cause of debility gives the poison activity The first indication is, therefore, answered by avoiding whatever may depress or weaken, and employing every plan to give a tone to the system. The depressing passions are consequently to be counteracted; and should the patient's mind rest on the circumstances of the bite, it should be cheered by every encouraging representation. Perhaps the ridiculous specifics, as eating the liver of the dog broiled, or tying the skin of an hyaena about the arm, may have been useful by inspiring confidence; and avoiding cold and excesses of every kind must be advantageous in every view. Stimulants are useful with the same design; and numerous are the remedies of this kind recommended by the ancients, though condemned by Boerhaave: viz. Galen's theriaca; Scribonius Largus' opiate, a preparation containing opium with large quantities of aromatics; the cibi acres of Dioscorides; the wine of Celsus; the garlic and theriaca of Palmarius and Mayerne, who added occasionally the scordium, the snake root, and the flowers of hypericum; and the pepper of Mead; are of this kind. Tonics have been also employed, the chief of which is cold bathing. The ancients used it with every mode of exciting terror; and when they used the warm bath in this complaint, the patient on coming out of the water was plunged"in piscinam." Other tonics have not been employed, though we find the filings of tin in Mayerne's remedy; and in some formulae, the varvain, the lesser sage, plantain, and polypody; and in others, the wormwood, mint, betony, hypericum, and lesser centaury - medicines which, if they have any power, must act as tonics.

In following the second indication, we may evacuate the poison from the wound by sucking, by washing it with hot water, by cutting it out, by bleeding with cupping glasses, by enlarging the wound, increasing the discharge with suppurating applications, by burning it with gunpowder, or destroying an absorbing surface by a caustic. Each has been employed, and each has had its partisans; but to cut out the part is the only certain remedy, and it is certain at any period previous to the inflammation. If the wound is inflicted so deep that the bitten part cannot be separated, a caustic must be applied to what remains; and though we thus lessen the chance of relief, we should reflect that, at the depth of the wound, the tooth has already lost its venom. Yet such are the horrid consequences, that even the loss of a limb would, in the event of a violent wound from a dog certainly mad, cheaply purchase security.