1. HEITZ, E.: Chromosomes structure. Z. Indudt Abslamm. u. Vererblehre 70:402, 1935.

2. GEITLER, L.: Grundriss der Zytologie. Berlin, 1934. GEITLER, L.: Chromosomenbau. Berlin, 1938.

3. NEBEL, B. R.: Chromonemata, number per chromosome. Cold Spring Harb. Symp. quant. Biol. 9:7, 1941.

5. BLIX, M.: Experimental contribution to the solution of the problem of the specific energy of skin nerves. Ztschr. f. Biol. 20:141, 1884; also Zlschr. f. Biol. 21:145, 1885.

6. GOLDSCHEIDER, A.: Gesammelte Abhandlungen. Leipzig. Barth. 1898.

7. STRUGHOLD, H.: Concerning the amount and threshold of the pain points of the epidermis in different parts of the body. Zlschr. f. Biol. 80:367, 1924.

8. von FREY, M.: Abhandlungen der matematisch physischen Classe der K. Sachsichen Gesellschaft der Wissenchaften. Leipzig. Bei S. Hirzel (III) 23:239, 1896.

9. WOOLARD, H. H.: Intradermal nerve endings. J. Anat. 71:54, 1936.

10. LEWIS, T.: Pain. MacMillan, New York, 1942.

11. von FREY, M.: Investigation of pain causing stimuli. Zlschr. f. Biol. 76:1, 1922.

12. LEWIS, T., and HESS, W.: Pain derived from skin and mechanism of its production. Clin. Sc. 1:39, 1933-4.

13. SCHUMACHER, G. A.: The influence of inflammation on the pain threshold of the skin in man. Proc. Assoc. Res. Nerv. Ment. Dis. 23:166, 1943.

14. TOWER, S. S.: Pain. Definition and properties of the unit for sensory reception. Proc. Assoc. Res. Nerv. Ment. Dis. 23:16, 1943.

15. LEWIS, T.: Nocifensor system of nerves and its reactions. Brit. M. J. 1:431, and 491, 1937.

16. WOLF, S., and WOLFF, H. J.: Pain arising from the stomach and mechanisms underlying symptoms. Proc. Assoc. Res. Nerv. Ment. Dis. 23:789, 1943.

17. WEDDELL, G.: Multiple innervation of sensory spots in skin. J. Anat. 75:441, 1941.

18. HEAD, H.: Studies in Neurology. London. Henry Frowde, Hodder Stoughton, Ltd. 1920. ADRIAN, F. D.: Afferent impulses in the organs and their effect on respiration. J. Physiol. 79:332, 1933.

19. FENG, T. P.: Reversible inexcitability of tactile endings in skin injury. J. Physiol. 103, 1933.

21. HARRISON, T. R.: Failure of the Circulation, p. 160, Baltimore, 1935. HALDANE, J. S., and PRIESTLY, J. D.: Respiration. Oxford, 1935.

22. CHRISTIE, R. V.: Dyspnea. A review. Quart. J. Med. 7:421, 1938.

23. REVICI, E.: Oxybiotic imbalances in biology. Role of lipids. Monaco Mediterranee Med. 8:1, 1941 (extra supplement).

24. DEBYE, P.: Polar Molecules. New York. Chem. Catalog, 1929. KARRER, P.: Organic Chemistry. New York. Elsevier Publ. Co., p. 71, 1947.

25. LE FEVRE, R. J. W.: Dipole Moments. New York. Chem. Publ. Co.. 1938.

26. PENNY, W. G.: The Quantum Theory of Valency. London. Methuen, 1935.

SIDGWICK, N. V.: The Electronic Theory of Valency. Oxford. Clarendon Press, 1929.

GORTNER, R. A.: Outlines of Biochemistry. London. Wiley & Son, 1947.

28. LEA, C. H.: Rancidity in edible fats. D. S. I. R. Food investigation special report No. 46. London, 1938; U. S. A., 1939.

30. FARMER, E. H.: J. Chem. Soc. 121, 139, 185, 518, 1942.

31. FARMER, E. H., and SUTTON, D. A.: J. Chem. Soc. 119, 122, 541, 1943.

BOLLAND, J. L., and KOCH, H. P.: J. Chem. Soc. 445, 1945. ATHERSON, D., and HILDITCH, T. P.: J. Chem. Soc. 105, 1944.

32. GUNSTONE, F. D., and HILDITCH, T. P.: J. Chem. Soc. 836, 1945.

33. LAPWORTH, A.: J. Chem. Soc. 121:417, 1922. INGELHOLD, C: Chem. Rev. 15:233, 1934.

35. KARRER, see 24.

37. REVICI, E.: Pathogenesis of infectious diseases. Bull. Soc. Med. Hopitaux, Bucharest, 1919.

38. REVICI, E.: Concerning the pathogenesis of contagious diseases. Rev.

Med. Pasteur 15:5, 1942.

39. FROISIER, J.: Etude Experim. Recentes Mai. Infect. Masson Pain. 1935.

40. REVICI, E.: The problem of shock. Rev. Med. Pasteur 16:97, 1943. RAVICH, R. A., and REVICI, E.: The effect of n butanol in sodium salt solutions upon shock and the survival of mice exposed to severe extensive thermal burns. Bull. Am. Soc. Hosp. Pharm. 8:23, 1951. Presented at annual meeting, A. A. A. S., Dec. 1950.

41. MAWRY, D. T., BRODE, W. R., and BROWN, J. B.: J. Biol. Chem. 142:671, 1942.

42. FOX, C. L., and KESTON, A. S.: The mechanism of shock from burns and trauma traced with radiosodium. Surg. Gynec. & Obst. 80:561, 1945.

FOX, C. L., and BAER H.: Redistribution of potassium, sodium and water in burns and trauma, and its relation to the phenomena of shock. Am. J. Physiol. 151:155, 1947.

43. SCHMIDT, O.: Density distribution and energy spectrum of B electrons:

IV. Mechanism of the excitation process in cancerous and healthy cells. Ztschr. f. physikal Chem. B 44:194, 1939.

SCHMIDT, O.: Characterization and mode of action of the carcinogenic hydrocarbons. Naturwiss 29:146, 1941.

SCHMIDT, O.: The mechanism of action of carcinogenic organic substances. Tumori 27:475, 1941.

SCHMIDT, O.: Relation between density distribution of definite balance electrons (B electrons) and reactivity of aromatic hydrocarbons. Ztschr. f. physikal Chem. B 39:59, 1938.

SCHMIDT, O.: The characterization of simple and carcinogenic aromatic hydrocarbons by the density distribution of definite valence electrons (B electrons). Ztschr. f. physikal Chem. B 42:83, 1939.

44. PULLMAN, A.: A relation between the distribution of electronic charges and the carcinogenic potency of a certain class of hydrocarbons. Comp. Rend. Acad. d. Sc. 221:140, 1945. DAUDEL, P., and DAUDEL, R.: On the physico chemical theory of the mechanism of action of carcinogenic substances. Acta Un. Int. Cancer 6:20, 1948.

DAUDEL, P., and DAUDEL, R.: The possible formation of a complex between carcinogenic substances and the tissues. Bull. Soc. Chim. Biol. 31:353, 1949.

DAUDEL, P., and DAUDEL, R.: Application of wave mechanics to the study of the mechanism of action of carcinogenic substances on the tissues. Biol. Med. 39:201, 1950.

DAUDEL, P., DAUDEL, R., and BUU HOI, N. P.: The problem of predicting the carcinogenic property of chemical substances. Acta Un. Int. Cancer 7:91, 1950.

DAUDEL, P., DAUDEL, R., BUU HOI, N. P., and MARTIN, M.: Molecular diagrams of mesomerism and reactivity of organic molecules. Bull. Soc. Chim. Fr. 15:1202, 1948.

45. WATERS, A. W.: Physical Aspects of Organic Chemistry, van Nostrand Co., New York, p. 39, 1950.

46. BOYLAND, E., and BRUES, A. M.: The carcinogenic action of dibenzcarbazoles. Proc. Roy. Soc. S. B. 122:429, 1937.

47. BIELSCHOWSKY, F.: Distant tumors produced by 2-amino- and 2acetyl aminofluorine. Brit. J. Ex per. Path. 25:1, 1944.

48. ENGEL, R. W., and COPELAND, D. H.: Mammary carcinoma in rats fed 2-acetyl aminofluorine. Science 108:336, 1948.

49. MORRIS, H. P., DUBNICK, C. S., DUNN, T. B., and WESTFALL, B. B.: Some observations on carcinogenicity distribution and metabolism of N acetyl-2 aminofluorine in rats. Acta Un. Int. Cancer 6:47, 1948.

POTTER, V. R., LE PAGE, G. A., and KLUG, H. L.: The essay of animal tissues for respiratory enzymes. VII: Oxalacetic acid oxidation and the coupled phosphorylation in isotonic homogenates. J, Biol. Chem. 175:619, 1948.

ELLIOT GREENSTEIN, J. P.: The biochemistry of malignant tissues. Am. Rev. Biochem. 14:643, 1945.

STERN, K., and WILLHEIM, R.: The Biochemistry of Malignant Tumors. Brooklyn, New York. Reference Press, 1943.

WEINHOUSE, S., MILLINGTON, R. H., and WENNER, C. E.: Occurrence of the citric acid cycle in tumors. J. Am. Chem. 72:4332, 1950.

50. ARMSTRONG, E. C, and BONSER, G: Epithelial tumors of the urinary bladder in mice induced by 2-acetyl aminofluorine.J. Path. & Bact. 56:507, 1944.

51. BIELSCHOWSKY, F., and GREEN, H. N.: An induced carcinoma in the fowl. Nature 156:780, 1945.

52. BIELSCHOWSKY, F.: The carcinogenic action of 2-acetyl aminofluorine and related compounds. Brit. M. Bull. 4:382, 1947.

53. TILAK, B. D.: In 23rd Annual Report of the British Empire Cancer Campaign, 109, 1946. TILAK, B. D.: Sulphur isosters of carcinogenic hydrocarbons: I. Proc. Indian Acad. Sci. 33 A: 131, 1951.

54. COOK, J. W., HEWETT, C. L., KENNAWAY, E. L., and KENNAWAY, N. M.: Effects produced in the livers of mice by azonaph thalenes and related compounds. Am. J. Cancer 40:62, 1940.

55. HADDOW, A., HARRIS, R. J. C, KON, G. A. R., and ROE, E. M. F.:

The growth inhibitory and carcinogenic properties of 4-aminostilbene and derivatives. Phil. Trans. Roy. Soc. A. 241:147, 1948.


Oestrogenic activity of certain synthetic compounds. Nature 141, 1938.

57. ROBSON, J. M., and SCHONBERG, A.: Oestrous reactions including mating, produced by triphenyl ethylene. Nature 140:196, 1937.

58. NETTLESHIP, A., and HENSHAW, P. S.: Induction of pulmonary tumors in mice with ethyl carbamate (urethane). J. Nat. Cancer Inst. 4:309, 1943.

59. LARSEN, C. D., and HESTON, W. E.: Induction of pulmonary tumors in mice by anesthetic agents. Cancer Research 5:592, 1945.

60. LARSEN, C. D.: Evaluation of the carcinogenicity of a series of esters of carbamic acid. J. Nat. Cancer Inst. 8:99, 1947 a. LARSEN, C. D.: Pulmonary tumor induction by transplacental exposure to urethane. J. Nat. Cancer Inst. 8:63, 1947 b.

61. LARSEN, C. D.: Pulmonary tumor induction with alkylated urethanes.

J. Nat. Cancer Inst. 9:35, 1948.

GESSEL, R., KRUGER, H., GORHAM, G, and BERNTHAL, T.: The regulation of respiration. Am. J. Physiol. 94:387, 1930.

COOK. L. C, and HURST, R. H.: Blood lactic acid in blood during rest. J. Physiol. 79:443, 1933.

WARBURG, O.: Experiments in surviving carcinoma tissue: Methods. Biochem. Ztschr. 142:317, 1923.

WARBURG, O.: The Metabolism of Tumors. London, 1930.

CORI, C. F., and CORI, G. T.: The carbohydrate metabolism of tumors: I. The free sugar, lactic acid, and glycogen content of malignant tumors. J. Biol. Chem. 64, 1925.

DICKENS, F.: Cancer as a problem in tissue metabolism. Cancer Rev. 57, 1931.

ELLIOT, K. A. C: Symposium on respiratory enzymes. Madison, Wise.

Univ. of Wisconsin Press, 1942. WARBURG. O.: On the origin of cancer cells. Science 123:309, 1956. WARBURG, O.: On respiratory impairment in cancer cells. Science 124:- 267, 1956.

BURK, D., and SCHADE, A. L.: On respiratory impairment in cancer cells. Science 124:267, 1956. ADAMS, D. H., and QUASTEL, J. H.: Factors influencing the anaerobic glycolysis of brain and tumour. Proc. Roy. Soc. (B), 145:472, 1956.

62. BURK, D.: Colloquial consideration of the Pasteur and nec Pasteur effects. Cold Spring Harbor Symposia on Quant. Biol. 7:420, 1939. Symposium on Respiratory Enzymes. Madison, Wisconsin. Univ. of Wisconsin Press, 1942. ORR, J. W.: The induction of pulmonary adenomata in mice by urethane. Brit. J. Cancer 1:311, 1947.

63. ALEXANDER, P.: The reactions of carcinogens with macromolecules. Advanc. Cancer Res. 2:1, 1954.

BURCHENAL, J. H., LESTER, R. A., RILEY, J. B., and RHOADS, C. P.: Studies on the chemotherapy of leukemia: I. Effect of certain nitrogen mustards and carbamates on transmitted mouse leukemia. Cancer 1:329, 1948.

BURNOP, V. C. E., RICHARD, D. E., WATKINS, W. M., and WOR MALL, A.: Combination of nitrogen-15, labelled nitrogen mustard with proteins. Nature 168:251, 1951.

CAMERON, G. R., COURTICE, F. C, and JONES, R. P.: The effects of BB'-dichloro diethyl methylamine hydrochloride on the blood forming tissues.J. Path. & Bad. 54:425, 1947. ROSS, W. C. J.: The chemistry of cytotoxic alkylating agents. Advances in Cancer Research. New York. Academy Press, 1952, Vol. 1. BURCHENAL, J. H., and RILEY, J. B.: Relation between structure and activity in the nitrogen mustards. Cancer Research 9:553, 1949.

65. BURCHENAL, J. H., RILEY, J. B., and LESTER, R. A.: Studies on the chemotherapy of transmitted leukemia in mice. Acta Un. Int. Cancer 6:448, 1949.