When the curves of various analyses obtained at the same time for the same subject were checked, an interesting relationship was found.

In patients with small localized tumors, only some of the analyses showed abnormal patterns. However, with the evolution of cancer toward the terminal stage, abnormal patterns became apparent for more and more analyses. In advanced cases, most of the analyses showed abnormal patterns.

It was especially in advanced stages that definite groupings of patterns with opposite characteristics could be recognized. They corresponded to two fundamental offbalances which we have called "Type A" and "Type D." ("A" for anoxybiosis, "D" for dysoxybiosis which represent the principal manifestations of oxygen metabolism in a phase of these offbalances.)

The correspondence between the different abnormal patterns defining the offbalance A or D, is seen in Figures 52 to 60. The abnormal pattern of the low urinary specific gravity appears together with a pattern of high values for the pH, both corresponding to the offbalance type A. (Fig. 52) A high urinary pH and low chloride index pattern correspond to the off balance type A, as seen in Fig. 53. The analyses of a case with low specific gravity, high pH, low chloride index and high surface tension, as present in offbalance type A, is shown in Fig. 54. An opposite case, offbalance type D, with high specific gravity, low pH, high chloride index and low surface tension is shown in Fig. 55. A similar case of offbalance type D is shown in Fig. 56 with high urinary specific gravity, low pH, low surface tension and low blood leucocyte number. In Fig. 57, the low pH, high sulfhydryl index and low surface tension show an offbalance of the type D.

Fig. 52. A correspondence is seen between the patterns of urinary specific gravity and that of the urinary pH in a cancer of the colon corresponding to the type A off balance. The changes still present in the curves are opposite.

The independence of the levels may explain why, in the same subject not all the analytical patterns obligatory concord at all times in the same subject. Especially when defense reactions intervene, the offbalance at one level can be different from that at other levels. Fig. 58 shows such examples. Usually, as the disease progresses, many of these differences disappear, the manifestations—analytical and clinical at different levels—entering in the same type of offbalance. Fig. 59 shows such an example.

Fig. 53. In a case of sarcoma of the leg with lung metastases the curve of the urinary pH is fixed above the average line (6.2) while the curve of chloride index below the average line of 2.5. This relationship indicates a type A of the offbalance.

Fig. 54. The analysis of a terminal case of cancer of the breast, showing the fundamental offbalance, low specific gravity, high pH, low chloride index and high surface tension, corresponding thus to the offbalance A.

The passage of a subject from one offbalance into the opposite one is seen to occur during the evolution of the condition most often induced by therapeutic attempts. Fig. 60 shows such an example.

The two opposite offbalances, identified first through the urine analyses, could be recognized to exist for all the manifestations taking place at the different levels of the organization. The manifestations seen at these levels could thus be interpreted as corresponding to one of the two opposite fundamental offbalances, type A and D. Table IV shows this coordination of the different manifestations according to the two opposite offbalances.

On the basis of all these data, clinical manifestations and analyses, the dualistic pathogenic concept appeared to be well established and the dualistic physiopathological mechanism studied in complex conditions in general and in cancer in particular.

Fig. 55. A terminal case of cancer of the breast shows all the analyses fixed in opposite position to the case of Fig. 54, i.e., high specific gravity, low pH, high chloride index and low surface tension, corresponding to an offbalance of the type D.

Fig. 56. Offbalance type D, shows high urine specific gravity, low pH, low surface tension and low blood leucocyte number.

Fig. 57. The 3 curves, pH, sulfhydryl index and surface tension show an offbalance type D.

Fig. 58. The urine analyses of a patient with cancer of the ovary, showing a discordance between the patterns present. While all the analyses show patterns of the type D, the chloride index remains throughout the entire observation constantly of type A.

Fig. 59. The passage of discordant patterns into their opposite patterns, in order to realize a concordant offbalance as seen in a case of cancer of the stomach. At the beginning of the observation, low pH values show a pattern corresponding to type D, while two other analyses—sulfhydryl index and surface tension—are of offbalance A. With the progress of the condition, sulfhydryl index and surface tension values pass gradually from offbalance A also to offbalance D.

Fig. 60. A condition can pass from one offbalance to the opposite one. The passage of the analyses from the offbalance type D into the offbalance type A is seen in a case of cancer of the lung. The analyses which first show high specific gravity, low pH and high chloride index, pass subsequently to the opposite side, with low specific gravity, high pH and low chloride index. This new offbalance remains unchanged for a long time as shown in the second part of the curve.