Collinsonia Canadensis, Stolle Root. This tough, fibrous root is exceedingly difficult of extraction, and the quickly made percolated fluidextracts of it are very inferior. It requires prolonged maceration. and only the green root should be used. Collinsonia is a tonic to the digestive organs and to enfeebled muscular structures, particularly non-striated muscular tissue. For this reason, it influences the heart and blood-vessels. In large doses it is the remedy in clergyman's sore throat and all straining of the vocal organs marked by aphonia, cough, and a sense of constriction. Dose, I5 I. ec. tr., in simple syrup, four times a day. In moderate doses Dr. John V. Shoemaker considers it an antispasmodic of great value in gastralgia. It is of recognized value in catarrhal gastritis, and is usually combined with hydrastis. (Ec. tr., 5 to 10 I.) In small doses it is highly useful in hemorrhoids and relaxed conditions of the lower bowel with imperfect venous capillary circulation. I regard it as the most valuable internal remedy we possess in such rectal states. In cardiac debility, especially that associated with chlorosis, it is of value. It is not a heart stimulant, but adds tone to the heart muscle and blood-vessels. (Ec. tr., I or 2 I.) There is no reason why a slowly made fluidextract should not be as active as the ec. tr., but, as a matter of fact, few makers take proper care with this non-official drug. It is a very valuable remedy, and should be largely used.