Colchicum. This agent has come into much undeserved disrepute. It must be remembered that large doses are cathartic and produce a very feeble pulse and cool skin. It is a valuable agent, but has been given in altogether too large doses. It is only after the pulse and temperature are reduced to near the normal that colchicum acts well. It is more valuable in chronic than in acute forms of rheumatism. It should usually be preceded by a saline laxative, and seems to act peculiarly well in combination with cimicifuga. Use doses of f.e. (seed), I to 2 I.; tr. of seed, I0 I.; ec. tr., I I., and you will be pleased with its action. A really good fluidextract is usually effective in doses of I 111.. Wine of colchicum is unnecessary. It impresses me as illogical to give wine to a rheumatic or gouty patient even in small quantities. Colchicine is used in doses of 1-120 to 1-30 gr. Colchicine salicylate in doses of 1-200 to 1-80 gr. These agents are very active, and should be employed with the utmost of conservatism.