Phosphorus (P = 30.77) is a non-metallic element, usually obtained from bones and certain minerals.

Pharmacodynamics.

Central Nervous System. - Little changed.

Muscular System. - Not affected except by the general tendency to fatty degeneration.

Respiration. - No known effect.

Heart. - Not affected, except in toxic doses.

Blood-pressure doesn't seem to be affected in any way.

Alimentary Tract. - Phosphorus induces a fatty infiltration of the epithelial cells. with sequent intercellular fibrosis. Bile salts are decreased; bile pigments increased at first, but later decreased; glycogen and lecithin reduced; increase of autolytic ferment,

Secretory Glands. - Fatty degeneration of the epithelium of the kidney.

Metabolism. - Phosphorus is a stimulant to the production of osteoblasts and of erythrocytes. It increases katabolism, especially of the liver, where a fatty infiltration soon ensues followed by intercellular fibrosis.

Temperature varies, sometimes rising, sometimes falling.

Absorption. - Phosphorus is absorbed with great difficulty, except when in a state of minute subdivision.

Excretion is obscure; some by kidneys, and some by the lungs.

Local Action. - May ignite and produce bad burns.

Symptoms.

Medicinal Doses.

No symptoms other than garlicky eructations.

Chronic Intoxication.

Cachexia. Slight jaundice. Anaemia. Albuminuria. Chronic enteritis. Necrosis of mandible. Cirrhosis of stomach, liver and kidney.

Acute Toxic Doses.

After several hours appear:

Gastric pain.

Nausea and garlicky eructations.

Bilious vomiting. (Diarrhea.) Apparent recovery, then after several days, a recurrence of above symptoms, plus

Gastric and hepatic tenderness.

Jaundice and bloody vomitus.

Physical malaise; weak pulse.

Lessened urine, casts, and blood.

Subcutaneous hemorrhages.

Exhaustion, collapse, coma, and death.

General fatty degeneration.

Therapeutics.

Phosphorus seems to be logically indicated in disturbances of bone development.

Dosage.

Pilulae Phosphori, 1 pill. (Each pill contains of phosphorus, 0.0006 Gm.)