Sodii Glycerophosphate. Sodium Glycerophosphate. (Not official.)

Source

By a method similar to that given above, a Sodium being substituted for a Calcium Salt.

Characters

A white, crystalline powder which is so hygroscopic that this salt appears in commerce only as a 75 per cent. solution in water.

Dose, 10 to 30 m.; .60 to 2.00 c.c., usually hypodermatically.

Potassium Glycerophosphate (not official) is similar in physical appearance to the Sodium Salt. Iron, Lithium and Magnesium Glycerophosphates (none official) are fine, white, soluble powders.

Action of the Glycerophosphates

According to Robin, the administration of these substances increases the solids of the urine, the urea, the carbon dioxide and sulphur oxidation coefficient, the chlorides, sulphates, lime, magnesia and potash, with but little effect on uric acid. They improve the nutrition of all organs, but more particularly that of the nervous system.

Therapeutics of the Glycerophosphates

Inasmuch as the urine of neurasthenics contains relatively large amounts of incompletely oxidized phosphorus, especially in the form of glycerophosphoric acid, the effort was made to replace this loss by the introduction of phosphorus into the organism in a form approaching, so nearly as is possible, that in which it exists in the nervous system. The indications for the glycerophosphates are conditions of nerve depression. If given subcutaneously they are at least as efficacious as testicular fluid (q. v.), which owes its activity to its contained organic phosphates, and possess the advantage of more accurate dosage. They are useful in various neuralgias, as sciatica, tic douloureux, Addison's disease, and in the symptom-complex, known as neurasthenia. Chlorosis, albuminuria, phosphaturia, anaemia, the latter by the iron salt, have been benefited. In diabetes the general condition improves and the amount of sugar may diminish. In various diseases of the bones, such as rachitis, osteomalacia, tuberculous affections, the lime and magnesium salts are indicated. The remedies should not be expected to rejuvenate senility, but are useful, even if slowly acting, adjuncts to the systematic treatment of impaired nervous systems.