Chcl3=119.08. A liquid consisting of 99 to 99.4 per cent., by weight, of absolute Chloroform, and I to 0.6 per cent. of Alcohol. Synonyms. - Chloroformum Purificatum. Trichloromethane.

Source

Heat water and Alcohol in a still to 100° F. 37.70 C, then add Chlorinated Lime; Chloroform distils over. It is believed that reaction takes place as follows: On bringing together Alcohol and Chlorinated Lime, the Chlorine converts the former into Chloral, which is at once decomposed by the Calcium Hydroxide, yielding Chloroform and Calcium Formate (Ca(Ch02),). The Calcium Formate is decomposed by another portion of Chlorinated Lime into Calcium Carbonate and Chloride, and water. 2C2H5OH +10CaOcl2=2Chcl3-+7CaCi2+2CaC03+Ca(OH)2+4H2O. In late years a Chloroform quite free from Chlorinated bye products has been obtained from the distillation of Acetone (from destructive distillation of Calcium Acetate) and Chlorinated Lime, from which Chloroform is produced, together with Calcium Acetate, Hydroxide and Chloride. 2(C3H6O)+6(CaOCl2)= 2(Chcl3)+Ca(C2H3O2)2+2Ca(OH )2+3CaCl2.

Characters

A heavy, clear, colorless, mobile and very diffusible liquid of a characteristic, ethereal odor, and a burning sweet taste. Sp. gr., not below 1.490. It imparts a green color to flame. Solubility. - In 200 parts of water, in which it sinks in heavy drops.

Impurities

Hydrocarbons, shown by darkening with sulphuric acid, non-volatile compounds, shown by not completely evaporating, and by unpleasant odor, acids, and free chlorine.

Purification

Chloroform which fails to respond to tests of the Pharmacopoeia should be purified by the following process: Chloroform, 400; Sulphuric Acid, 80; Dried Sodium Carbonate, 20.gm.; Deodorized Alcohol, 4 c.c. Add the Sulphuric Acid to the Chloroform, contained in a glass-stoppered bottle, and shake them together occasionally during twenty-four hours, avoiding exposure to bright daylight. Separate the lighter Chloroform layer; add to it the Dried Sodium Carbonate, previously rendered anhydrous by heating it in a porcelain capsule on a sand bath until it ceases to give off aqueous vapor, and shake them together frequently and thoroughly during half an hour. Then transfer the Chloroform to a dry retort, add to it the Alcohol; and distil, by means of a water-bath, at a temperature not exceeding 153° F., 67.2° C, into a well-cooled, tarred receiver, until the distillate measures

255 c.c.

Dose, 2 to 20 m.; .12 to 1.20 c.c

Preparations

1. Aqua Chloroformi. Chloroform Water

Aqua Chloroformi. Chloroform Water. Chloroform and distilled water, by agitation, there being always an excess of Chloroform present.

Dose, 1 to 4 fl. dr.; 4. to 15. c.c

2. Linimentum Chloroformi. Chloroform Liniment

Linimentum Chloroformi. Chloroform Liniment. Chloroform, 300; Soap Liniment, 700.

3. Emulsum Chloroformi. Emulsion Of Chloroform

Emulsum Chloroformi. Emulsion Of Chloroform. Chloroform, 40; Expressed Oil of Almond, 60; Tragacanth, 15; water to 1000.

Dose, 1 to 4 fl. dr.; 4. to 15. c.c

4. Spiritus Chloroformi. Spirit Of Chloroform

Spiritus Chloroformi. Spirit Of Chloroform. Synonym.- Chloric Ether. Chloroform, 60; Alcohol, 940. Strength. - 6 per cent.

Dose, 1/2 to 1 fl. dr.; 2. to 4. c.c

5. Tinctura Chloroformi et Morphinae Composita, B. P., not official. Compound Tincture of Chloroform and Morphine. - Intended to be an imitation of the proprietary medicine called Chlorodyne. Mix Chloroform, 75; Tincture of Capsicum, 25; Tincture of Indian Hemp, 100; Oil of Peppermint, 1.5; and Glycerin, 250; with Alcohol, 450; and dissolve in this Morphine Hydrochlorate, 10; add Diluted Hydrocyanic Acid, 50; then mix with sufficient Alcohol to form 1000 parts.

Strength

10 m. .60 c.c contains chloroform m. .045 c.c, morphine hydrochlorate, 1/11 gr., .0054 gm., diluted hydrocyanic acid 1/2 m. .03 c.c

Dose, 5 to 15 m.; .30 to 1.00 c.c