Salamide

A pinkish, crystalline substance, obtained by the action of ammonia on methyl salicylate. Soluble in alcohol and ether, and used like the salicylates in similar doses.

Salen

A mixture of methyl-and ethyl-glycol salicylates. An oily, odourless liquid, used as an antirheumatic. Salenal is a l-in-3 ointment of the same.

Salibromin

Dibromsalicylic methyl ester, a white powder, soluble in alkalies, and used as an antirheumatic and antipyretic. Dose: 10 to 15 grains.

Salicylamide C6H4.OH.CONH2. Colourless crystals, slightly soluble in water. Dose:2 to 4 grains.

Salifebrin, or acetanilide salicylate, is an antipyretic and anti-neuralgic in doses of 5 to 10 grains.

Saliformin

See Formin.

Saligallol

Trade-name for a 33-per-cent. solution (in acetone) of pyrogallol disalicylate. Used (diluted with acetone) as a varnish in skin-diseases.

Saligenin, sometimes called dia-thesin is obtained by the hydrolysis of salicin, or by combining phenol and formaldehyde. Colourless crystals, almost insoluble in water, but soluble in alcohol. Dose:7 to 15 grains in cases of acute rheumatism.

Salimenthol

Menthol salicylic ester, a yellowish liquid; sedative and antiseptic. Dose: 4 grains, in capsules. Samol is an ointment containing 25 per cent.

Salipyrin, or antipyrin salicylate.-A colourless and odourless powder, insoluble in water, of a sweetish taste, formed by the interaction of antipyrin and salicylic acid. Possesses the medicinal properties of its constituents. Dose: 5 to 15 grains, in powder or tablets.

Salitannol

A compound of equal molecular proportions of salicylic and tannic acids. Is a white, amorphous powder, insoluble in water, used as a substitute for iodoform.

Salite, the salicylic ester of borneol, is an oily liquid, insoluble in water. Dose: 3SS. in rheumatism, or rub with a solution of 1 part in 2 of olive oil.

Salocoll, or phenocoll salicylate. A white, crystalline powder, soluble in water. Antirheumatic and antipyretic. Dose:5 to 15 grains. Salicol is a French cosmetic solution of salicylic acid and winter-green oil in weak alcohol.

Salol Camphor is a mixture of salol 3 parts and camphor 2 parts, rubbed together until liquefied.

Salophen, or acetyl-para-amido-salol, occurs in white scales, insoluble in water. For rheumatism and neuralgia. Dose:15 grains.

Saloquinine, or salicyl-quinine (chinin in German), is the base of rheumatin. Insoluble in water. An antipyretic in typhus, etc. Dose: 5 to 10 grains.

Salossit

A compound of calcium, magnesium, and phosphorus with organic substances and milk sugar (95 per cent.), given in rickets as a substitute for cod-liver oil.

Salubrol is an antipyrin derivative (C23H24N402Br4), an orange-yellow powder used instead of iodoform. Insoluble in water, soluble in alcohol.

Salvarsan ('606').-Dioxy-diaminoarsenobenzol dihydrochlo-ride, C12H6As2(OH),(NH2)2(HCl)2 An antisyphilitic claimed to exert a specific action on the spirochete. Put on the market in sealed tubes, each containing 0.6 gramme, which is the dose for injection, intramuscular or intravenous. Full directions are given with each tube for preparing the injection - substantially by mixing the substance with water and a sufficiency of sodium-hydrate solution to neutralise. According to Dr. W. H. Martindale (C. & D., Ixxvii. 897), these are not strictly accurate. The following description by him of the preparation of the injection shows what takes place (0.3 gramme was used in this case):

The salvarsan was placed in a small glass mortar and rubbed with 5 c.c. of water, in which quantity it is easily soluble; decinormal sodium-hydrate solution was then added from a burette; a precipitate formed, which redissolved until 5.8 c.c. had been added. The mixture became gelatinous when 6.4 c.c. had been added, and looked somewhat like melted yellow petroleum-jelly, becoming thinner again on further addition of alkali (6.8 c.c. according to theory is required to produce the mono-hydrochloride). Adding the alkali further, it was found that 12 c.c. approximately in all was requisite to neutralise, litmus-paper being used, which indicates the formation of the base (theory demands 137 c. c.). Adding alkali further, the precipitate visibly diminished, an almost clear solution being formed when 18 c.c. in all had been added (theory demands 20.5 c.c. for the formation of the mono-sodium compound - the third stage in the matter). The addition of a further quantity of alkali (up to 27.4 c.c.-the amount theoretically necessary for the di-sodium compound) did not render the solution absolutely clear, but filtration would effectually remove the slight opalescence.

For intravenous use a more dilute solution is advised by the makers- viz., 0.5 gramme is to be treated with 0.95 c.c. of 15 per cent. by weight of sodium-hydrate solution, the liquid being finally diluted to about 200 c.c.

Sanguinarine, the alkaloid of blood-root, should be distinguished from the resinoid sanguinarin. Dose of the alkaloid or its salts (nitrate and sulphate):1/20 to 1/10 grain.