It is antiseptic and destructive to low forms of life. Internally it is a stimulant expectorant, and acts as a disinfectant to the alimentary canal. The latter action is a local one, as it is not readily absorbed into the system, but is mostly carried away by the faeces, that part of it taken up by the blood being excreted by the urine partly unchanged and partly as naphtol. Externally it is used as an antiseptic.
Derived from naphthalin; soluble in alcohol, ether, chloroform, oil, and vaseline. It is more easily absorbed than naphthalin, and causes vomiting, haema-turia, convulsions, and unconsciousness. In medicinal doses it is an intestinal disinfectant, in doses of gr. i.-iv. (0.065-0.25 Gm.). It is also used as a local application, dissolved in alcohol, in from 1 to 50 %.
Allied to naphthol, all unofficial, are:
Chinolin. Not official.
Chinolin is a derivative of cinchona bark, from which it is named, and is also found in coal-tar oil. It is made synthetically by the action of glycerin on nitro-benzol and aniline. It is a colorless, oily liquid, and on exposure to the air turns dark. Like an alkaloid, it combines with acids to form salts. It is antiseptic.
After a full dose there is a short preliminary stage of excitement, with increased pulse and a feeling of warmth, followed by perspiration, fall of temperature, slow and weak pulse, and lessened respirations. In large doses it diminishes reflex action and causes dyspnoea, paralysis, and collapse. Only one salt, the tartrate, is used medicinally.
Chinolin is not in general use, and is here placed before some of the more practically important antipyretics in an introductory way. Many of these medicines, which are synthetically prepared in laboratories, are the results of experiments made in the attempt to produce an imitation of quinine, and several different ones are derived from chinolin.