Much discredit has fallen upon Iodine from the heroic doses in which it is occasionally prescribed. Lugol commences with gr. ss. of Iodine, and gr. j. of the Iodide of Potassium daily, and gradually increases the dose, but never exceeds one grain of Iodine daily. All the best authorities agree in advising the remedy to be given in small doses. Baudelocque advises 1/6 of a grain, and Dr. T. Smith 1/10 of a grain, thrice daily. Lugol's formulAe are amongst the best which can be employed. They are as follow: -
gr. j 1/2,
AquAe f viij.
At the commencement of treatment, two-thirds of No. 1 is to be given daily; in the second fortnight the whole may be given. This may be gradually increased, until the whole of No. 3 is taken; but the latter is never to be exceeded. Great stress is laid by Lugol upon the time the medicine is exhibited; he recommends the first dose, consisting of half the daily quantity, to be taken before breakfast, and the second in the afternoon, an hour before dinner. His other formulas are: -
2. Solutions for external use, lotions, injections, &c.
Iodide of Potassium ..
* Op. cit., p. 23. Op. cit., p. 248. Lancet, No. 1268.
§ Selections in Pathology and Surgery, Lond. 1839, p. 51.
|| Sir F. Smith, Dub. Journ., July 1841.
• - ℞ Iodinii 3iv., Potas. Iod. j., Aq. Dest. f vj., M.
4. Caustic Solution: - ℞ Iodinii j., Potas. Iod. j., Aq. Dest. f ij., M.
5. Ioduretted Ointment: - ℞ Iodinii gr. xij., Potas. Iod. iv., Adipis ij., M.
Potas. Iod. Grains.
Potas. Iod. Drachms.
N.B. The vessels should be made of wood or marble, as Iodine forms soluble compounds with zinc, tin, and lead. The syringes used for injections should be of glass.
A caustic solution of Iodine in Glycerine is proposed by Dr. Max Ritcher.* It is prepared by first dissolving ss. of Iodine in f j. of Glycerine, and subsequently adding another ss. of Iodine, which completely dissolves in a few hours. It is applicable to all the usual forms of Scrofulous and Syphilitic Affections, but is especially useful in Lupus. The pain it causes, more or less intense, rarely lasts for more than two hours.