A preparation belonging to the phenol group; a decided antipyretic, being also antiseptic, sedative, and analgesic. After large doses profuse sweating is the first result, appearing in from thirty to fifty minutes, and in one or two hours the temperature begins to fall, reaching its lowest point in about four hours. The reduction is quite marked, averaging about 3°, while a fall of 5° or 6° has been known. Some depression may follow - not severe enough usually to be alarming - with weak and chilly feelings and weakened pulse. The rise of temperature is more gradual than the fall. In comparison with the activity of other antipyretics, ten grains of phenacetin are said to equal fifteen grains of antipyrine or quinine, and thirty grains of salicylate of soda, and to be equal in power with antifebrine, though less rapid in action and more enduring in its effect.

An eruption of the skin sometimes occurs in anaemic patients.

Phenacetin is almost insoluble in water, and is given dry on the tongue, or in compressed tablets, or capsules.

Average dose, gr. v.-0.3 Gm.

Allied to phenacetin, all unofficial, are:

Iodophenine. Methacetin.


Phenocoll Hydrochloride.

Exalgine. Not official.

A preparation similar to, and derived from, acetanilid. It has analgesic power, and the name was given with reference to this quality, and does not describe its chemical constitution, as do many of the names of new remedies. It is hypnotic and anodyne, and comparatively free from ill after-effects.

Its action in the relief of pain is rapid. In some cases, dizziness, trembling, weakness of the knees, and loss of muscular power in the eyelids have appeared almost immediately after its administration, passing oft in a short time.

It is given dry on the tongue, in powder or in tableta

Average dose, gr. iii.- 0.2 Gm..)