Charles Caldwell, an American physician, born in Caswell co., N. C, May 14, 1772, died in Louisville, Ky., July 9, 1853. He was the son of an emigrant Irish officer. In 1792 he went to Philadelphia, and joined the medical classes of the university. Here he applied himself earnestly to study and practice, and during the yellow fever of 1793 distinguished himself by ability, courage, and zeal. He acted as surgeon to a brigade during the whiskey insurrection. In 1795 he published a translation of Blumenbach's "Elements of Physiology," from the Latin. He succeeded Nicholas Bid-die as editor of the "Port Folio," and in 1816 edited Cullen's " Practice of Physic," while at the same time he filled the chair of natural history in the university of Pennsylvania. In 1819 he published the "Life and Campaigns of General Greene," and soon after became professor of medicine and clinical practice at the Transylvania university, Lexington, Ky. In 1820 he made a tour in Europe to purchase books and philosophical apparatus for that institution.

In 1837 he established in the city of Louisville a medical institute, but, in consequence of a misunderstanding with the trustees, was removed from office in 1849. He passed his latter days in Louisville, engaged in the composition of his autobiography, which appeared after his death. His works also include " Memoirs of the Rev. Dr. Horace Holley," and "Bachtiar Nameh, or the Royal Foundling, a Persian Tale, translated from the Arabic".