The preparations and usual doses are:

Propionic adlehyde: 10% sol.—for oral administration, used from 50-1000 mgr. daily; for parenteral administration: 2% sol. in saline.

Epichlorohydrin: 0.5% solution in isotonic saline, used from 1/10 mgr. to hundreds of milligrams daily for parenteral and oral administration.

Hexyl or heptyl diselenide: in solutions from 20 micrograms to 50 mgr./cc. for intramuscular injection. Orally, we use either capsules containing from 10 micrograms to 10 mgr. or, still better, a solution of 0.4% in oil, which corresponds to 100 micrograms per drop. The doses vary from 10 micrograms to 50 mgr. or more daily.

Tetralin perselenide: This preparation has 40 mgr. of selenium for 100 gr. of tetralin and is used orally as drops, from a solution of 10% or 1 % in oil. For injections, a solution containing 10% in 100 cc. of sesame oil, is used in doses ranging from 0.1 cc. to 10 cc. daily. Instead of tetraline, naphthalene or other aromatic hydrocarbons are used. One cc. of a 10% solution of these preparations in oil, contains 0.1 mg. of selenium; the doses used range from 0.1 cc. to 10 cc. daily.

Sodium or magnesium thiosulfate is used in a 10% solution for oral administration or in a 4% solution for intramuscular injection in doses ranging from 25 mgr. to 5 grams or more daily.

Tetraline persulfide: This preparation contains 5% sulfur in oil and is used orally from cc. to more than 10 cc. daily. In intramuscular injections it is used from 1/10 cc. to 2 cc. daily.

The acid lipids mixture is a solution in oil of 1% bixin, 2% cow liver lipoacids and 7% cod liver oil fatty acids. It is administered in doses of from 1/2 cc. to 6 cc. daily by intramuscular injection.

Heptanol in a solution of 0.5% or 5% in oil is used for parenteral administration; a solution of 5% in oil is employed for oral administration. The doses range from 1 mg. to hundreds of mgs. a day.

Polyunsaturated alcohols are safflower oil fatty acids with the carboxyl changed to a primary alcohol. They are used in a 10% solution in oil with 1/4 to 2 cc. injected intramuscularly up to four times a day.

Butanol in a 6.5% water solution is used for oral administration. A 6.5% saline solution is employed for parenteral administration. Usual doses are from 1/4. to more than 100 cc. daily.

Glycerol is used as a 50% solution for oral administration or as a 20% solution for parenteral administration in doses ranging from less than 0.2 gram to a few grams daily.

Insaponifiable fraction of pork liver in a 5% solution in oil is used for intramuscular injections in doses from Vi cc. to 8 cc. daily.

A preparation of a mixture of polyunsaturated alcohol, heptanol and butanol also is used for oral or parenteral administration.

If, during treatment, any other medications appear necessary for various concomitant conditions, it is preferable to choose them with consideration given to the influence they will exert upon the patterns present.

Table XXIII shows the effects of some commonly used therapeutic agents upon the fundamental offbalances, which would indicate their use in cases with one or the other offbalance.

Table XXIII. Effects Upon Offbalances A And D Of Various Agents Used Therapeutically

Having an anti A effect

Having an anti D effect

Dicoumarol

Glycerol

Glucose

Digitalis

Coramine

Antipyrine

Acetyl salicylic acid

Aminopyrine

Acetophenetidine

Atropine

Procaine

Quinine

Codeine

Morphine

Demerol

Caffeine

Aminophylline

Liver extracts

Iron

Vit. A, D, B.

Vit. B1, B2, K. E

Testosterone

Progesterone

Stilbesterol

Epinephrine

Desoxycorticosterone

Glucosamine

Penicillin

Streptomycin

Aureomycin

Cortisone

Sulfas

Insulin

Barbiturates

Mercuhydrine

Benzedrine

Benadryl

In using the various agents, we have to keep in mind the effect upon the existing offbalances.

Conduct of Treatment: Although there may be some variations depending upon the circumstances of individual cases, treatment is conducted generally as follows:

Urine and blood analyses are performed. Values for two or three consecutive days are usually determined before starting treatment. If all values indicate the same pattern, the diagnosis of the offbalance is clear. If the analyses indicate the presence of different patterns, an interpretation is made on the basis of analyses showing the offbalance at specific levels. For patients in whom manifestations involve the metazoic compartment, urinary surface tension is the important criterion. Urinary specific gravity and urinary pH, are important when systemic or tissular manifestations are present. Potassium is the criterion when changes at the cellular level are most important. The body temperature and the other complementary analyses are used when discordant patterns are encountered. They help to recognize the type of offbalance at the different corresponding levels.

Table XXIV. Agents Chosen According To The Tests

Agents

Level

Test

Offbalance A

Offbalance D

Cellular

Potassium in blood Urinary calcium

Selenium preparations Epichlorohydrin

Heptanol

Tissue

Urinary pH Blood eosinophiles Surface

Tension Pain pattern

Lipoacids

Tetralin persulfides Hydropersulfides Mg Thiosulfate

Polyunsaturated alcohols Unsaponifiable fraction liver Glycerol Butanol

Organ and Organism

Urine specific gravity Surface

Tension Body temperature

Mg or Na Thiosulfate Propionic aldehyde

Glycerophosphoric or lactic acid

Once the level offbalances are determined, suitable treatment is instituted. The agent is chosen from the proper group according to the level to be influenced. Since, in invasive cancer, the offbalance occurs at the cellular level, the agents used are selenium preparations and epichlorohydrin, for the offbalance A and heptanol for the offbalance D.

For the tissue level, indicated by pain as well as by urinary pH or eosinophiles, lipoacid preparations, Mg thiosulfate and Tetralinpersulfides are used for offbalance A, and polyunsaturated alcohols, unsaponifiable fractions and glycerol and butanol for offbalance D.

For the organ and systemic levels, with the offbalance recognized through urinary specific gravity, surface tension and body temperature, magnesium or sodium thiosulfate and propionic aldehyde are used for off balance A, and glycerophosphoric acid for offbalance D. (Table XXIV)