Prep.: 1. Liquor Sodii Arsenatis. Solution of Sodium Arsenate. (Syn., Liq. Sod. Arsen., Solution of Arseniate of Sodium; Fr. Liqueur (Solute) d'Arseniate de Soude; Ger. Arsensaure Natronlosung.) Manufacture: 1 p. c. Dissolve exsiccated sodium arsenate 1 Gm. in distilled water q. s. 100 Gm.; this aqueous solution contains .975-1.025 p. c. of sodium arsenate, and while it is a substitute for Pearson's Solution, the latter, it should be remembered, is only one-tenth as strong as the official liquor. Dose, eij-6 (.2-.4 Ml. (Cc.)), diluted. Unoff. Prep.: Liquor; Sodii Arsenatis, Pearson, .1 p. c. Properties and Uses. - Similar to arsenic trioxide. Liquor - identical with liquor potassii arsenitis in strength, but is said to cause poisoning less easily and does not irritate stomach so readily. Used in same diseases as arsenic trioxide - neuralgia, chronic malaria, nervous debility, chorea, eczema, anaemia, etc. Poisoning: Same as for arsenic trioxide.
Sodii Cacodylas. Sodium Cacodylate, Na(CH3)2AsO2. - (Syn., Sod. Cacodyl., Sodium Dimethylarsenate, Sodium Cacodylate; Fr. Cacodylate de Soude; Ger. Natriumkakodylat.)
Manufacture: Distil arsenous oxide with potassium acetate, oxidize distillate (cacodyl, As2(CH3)4, and cacodyl oxide, As2(CH3)4O), with mercuric oxide, neutralize cacodylic acid with solution of sodium hydroxide, concentrate to crystallization. It is in white, odorless, deliquescent prisms, granular powder, soluble in water (.5), alcohol (2.5); contains 72-75 p. c. of pure salt, and variable amount of water of crystallization. Tests: 1. Melts in its water of crystallization at
60° C. (140° P.), becomes anhydrous at 120° C. (248° P.), burning with bluish flame of garlic-like odor. 2. Aqueous solution (1 in KM)) few drops, + hypophosphorous acid 2 Ml. (Cc), let stand in stoppered tube - odor of cacodyl in an hour. Impurities: Heavy metals, mono-mcthylarsenate, arsenate, chloride, phosphate, sulphate. Should be kept in well-closed containers. Dose, gr. 1/2-2 (.03-.13 Gm.), in pill, enema, hypodermically.
Properties and Uses. - Alterative, haematic - similar to other arsenic compounds, but much less toxic and prone to undesirable effects, owing to slow liberation of arsenous acid in the body: psoriasis, leukemia, chlorosis, ansemia, tuberculosis, malarial cachexia, diabetes, chorea, skin diseases.
Sodii Cyanidum. Sodium Cyanide, NaCN. - (Syn., Sod. Cyanid., Natrium (Sodium) Cyanatum; Fr. Cyanure de Sodium (Soude); Ger. Natriumcyanid, Cyannatrium.)
Manufacture: (1) Fuse sodium carbonate with calcium cyanide, leach the melt with hot water, filter, evaporate'; (2) heat metallic sodium, coal, and sodium cyanide with ammonia at above the melting point of sodium cyanide; (3) pass hydrocyanic acid gas into alcoholic solution of sodium hydroxide, when sodium cyanide separates as a bulky crystalline precipitate. It is in white, opaque, amorphous pieces, white, granular powder, odorless (dry), deliquescent in the air, emitting odor of hydrocyanic acid (must use great caution in handling), freely soluble in cold water; aqueous solution (1 in 20) strongly alkaline, emitting odor of hydrocyanic acid; contains 95 p. c. of pure salt. Tests:
1. Fuses at low red heat, produces intense yellow flame; aqueous solution (1 in 20) few drops, with silver nitrate T. S. - white precipitate, soluble in excess of sodium cyanide solution or ammonia water.
2. Aqueous solution 5 Ml. (Cc.) with a few drops each of ferrous sulphate T. S. and ferric chloride T. S., + slight excess of hydrochloric acid - blue precipitate (iron ferrocyanide). Impurities: Ferrocyanide, sulphocyanate. Should be kept dark, in well-closed containers. Dose, gr. 1/20-1/4 (.003-.015 Gm.), dissolved in water.
Properties. - Same as cyanide of potassium, and hydrocyanic acid as a poison and medicine. Sedative, antispasmodic, anodyne.
Uses. - Spasmodic cough, nervous irritability, dyspnoea, asthma, phthisis, catarrh, whooping-cough; headache from dyspepsia,menstruation, etc.; very fleeting and dangerous (full dose), hence rarely employed. Poisoning: Similar to hydrocyanic acid; place in recumbent position, give fresh air, iron mixture (iron sulphate, gr. 10 (.6 Gm.) + tincture ferric chloride 3j (4 Ml. (Cc.)) + water ℥j (30 Ml. (Cc.)), emetics, atropine, stimulants (ether, brandy, inhale ammonia, warmth), demulcents.
Sodii Glycerophosphas. Sodium Glycerophosphate, Na2C3H7PO6. - (Syn., Sod. Glycerophos., Sodium Glycerophosphate, Disodium Monoglycerophosphate, Hydrated Sodium Glycerophosphate, Sodium
Glycerino-phosphoricum; Fr. Glycerophosphate de Sodium (Sonde); Ger. Natriumglycerinophosphat.)
Manufacture: Neutralize a solution of glycerophosphoric acid with sodium carbonate or bicarbonate, concentrate filtrate. It is in white, monoclinic plates, scales, white powder, saline taste, odorless, very soluble in water (cold, hot), nearly insoluble in alcohol; aqueous solution (1 in 20) alkaline; contains 68 p. c. of anhydrous salt. Tests: 1. When strongly heated - decomposes, evolving inflammable vapors; at red heat - converted into sodium pyrophosphate. Impurities: Heavy metals, free alkali, phosphates, alcohol-soluble substances. Dose, gr. 5-10 (.3-6 Gm.), ter die, in powder or subcutaneously.
Preparations. - 1. Liquor Sodii Glycerophosphatis. Solution of Sodium Glycerophosphate. (Syn., Liq. Sod. Glycerophos.; Fr. Solute Glycero-phosphate de Soude; Ger. Natriumglycerinophosphat.)
Manufacture: An aqueous solution of glycerophosphate containing not less than 50 p. c. of the anhydrous salt. It is a clear, colorless, yellowish, more or less syrupy liquid in other respects conforming to reactions and tests for purity under sodii glycerophosphas. Dose, ev-15 (.3-1 Ml. (Cc.)).
Unoff. Prep.: Elixir Glycerophosphatum Compositum, 4 p. c. (solution), + calcium glycerophosphate 1.6, ferric glycerophosphate .3, soluble manganese glycerophosphate .2, quinine glycerophosphate .1, strychnine glycerophosphate .015, lactic acid 1, +