Opium dried at a temperature not exceeding 185o F.; 85° C., and reduced to a very fine powder.

Powdered Opium, for pharmaceutical or medicinal purposes, when assayed, should yield not less than 13 nor more than 15 per cent. of Crystallized Morphine. Any Powdered Opium of a higher percentage may be brought within these limits by admixture with Powdered Opium of a lower percentage, in proper proportions.

Dose, 1/4 to 2 gr.; .015 to .12 gm.

Preparations

1. Extractum Opii. - Extract of Opium. Powdered Opium, 100; Distilled Water, 1000; Sugar of Milk, a sufficient quantity; by trituration, filtration and evaporation.

Dose, 1/8 to 1 gr.; .008 to .06 gm.

2. Emplastrum Opii. - Opium Plaster. Extract of Opium, 60; Burgundy Pitch, 180; Lead Plaster, 780; water, 80.

3. Trochisci Glycyrrhizae et Opii. - Troches of Glycyrrhiza and Opium. Extract of Glycyrrhiza, 15; Powdered Opium, 0.5; Acacia, 12; Sugar, 20 gm.; Oil of Anise, 0.2 c.c. To make 100 troches. Each troche contains about 1/12 gr.; .005 gm., of Opium.

Dose, 1 to 4 troches.

4. Vinum Opii. - Wine of Opium. Synonym. - Sydenham's Laudanum. Powdered Opium, 100; Cassia Cinnamon, 10; Cloves 10; Alcohol, 150; White Wine to 1000; by maceration and filtration.

Dose, 3 to 20 m.; .20 to 1.20 c.c.

5. Pilulae Opii. - Pills of Opium. Powdered Opium, 6.5; Soap, 2 gm. To make 100 pills. Each pill contains 1 gr.; .06 gm., of Opium.

Dose, 1 to 2 pills.

6. Pulvis Ipecacuanhae et Opii. - Powder of Ipecac and Opium. Synonym. - Dover's Powder. Powdered Opium, 10; Ipecac, 10; Sugar of Milk, 80.

Dose, 3 to 15 gr.; .20 to 1.00 gm.

7. Acetum Opii. - Vinegar of Opium. Synonym. - Black Drop. Powdered Opium, 100; Nutmeg, 30; Sugar, 200; Diluted Acetic Acid to 1000; by maceration and percolation.

Dose, 3 to 20 m.; .20 to 1.20 c.c.

8. Tinctura Opii. - Tincture of Opium. Synonym. - Laudanum, Powdered Opium, 100; Alcohol, 400; Water, 400; Diluted Alcohol to 1000; by maceration with Precipitated Calcium Phosphate, 50; and percolation.

Dose, 3 to 20 m.; .20 to 1.20 c.c.

9. Tinctura Opii Camphorata. - Camphorated Tincture of Opium. Synonym. - Paregoric. Powdered Opium, 4; Benzoic Acid, 4; Camphor, 4; Oil of Anise, 4; Glycerin, 4; Diluted Alcohol to 1000; by maceration and percolation.

Dose, 1 to 4 fl. dr.; 4. to 15. c.c.

10. Opium Deodoratum. - Deodorized Opium. Synonym.- Opium Denarcotisatum. Powdered Opium (containing 13 to 15 per cent. of Morphine), 100; macerated with Ether, 700; the clear solution poured off, and macerated twice with Ether, 350. The residue is dried and mixed with Sugar of Milk by trituration to weigh 100 parts.

Dose, 1/4 to 2 gr.; .015 to .12 gm.

11. Tinctura Opii Deodorati. - Tincture of Deodorized Opium. Powdered Opium, 100; Ether, 200; Alcohol, 200; Water to 1000. By maceration with Precipitated Calcium Phosphate, 50; by percolation and evaporation.

Dose, 3 to 20 m.; .20 to 1.20 c.c.

12. Tinctura Ipecacuanhae et Opii. - Tincture of Ipecac and Opium. Tincture of Deodorized Opium, 1000; Fluid Extract of Ipecac, 100; Diluted Alcohol to 1000; by evaporation and filtration.

Dose, 3 to 15 m.; .20 to 1.00 c.c.

It will be noticed that from Extract of Opium there is prepared Emplas-trum Opii, and from the Deodorized Tincture, Tinctura Ipecacuanhae et Opii.

The following non-official preparations are sometimes used: - Nepenthe, of the same strength as Laudanum, Liquor Opii Sedativus (Battley's solution), which is about 50 per cent. stronger than Laudanum, Acetum Opii Crocatum (black drop), four times as strong as Laudanum, and Tinctura Opii Ammon-iata, B. P. (Scotch Paregoric), about two and one-half times as strong as the Camphorated Tincture.

The following list, in which the doses are arranged, may assist the student:

Name.

Dose.

- Extractum Opii.........................

1/8 to 1 gr.; .008 to .06 gm.

- Opii Pulvis....................

1/4 to 2 gr.; .015 to .12 gm.

- Opium Deodoratum ....

- Pulvis Ipecacuanhae et Opii

3 to 15 gr.; .20 to 1.00 gm.

- Tinctura Ipecac et Opii .

3 to 15 m.; .20 to I.00 c.c.

- Vinum Opii...................

3 to 20 m.; .20 to 1.20 c.c.

- Tinctura Opii........................

- Tinctura Opii Deodorati .

- Acetum ......................

- Tinctura Opii Camphorata . .

1 to 4 fl. dr.; 4. to 15. c.c.

- Pilulae Opii......

1 to 2 pills.

- Trochisci Glycyrrhizae et Opii

1 to 4 troches.

- Emplastrum Opii ....

Externally.

Acidum Meconicum. - Meconic Acid

Source (not official). H3C7Ho7 =199.51.

Source

Calcium Meconate, which is precipitated in the manufacture of Morphine Hydrochlorate, is placed in hot water and treated with Hydrochloric Acid. On cooling, Meconic Acid crystallizes out.

Characters

Almost colorless, micaceous crystals.

Solubility

In 150 parts of water; in 45 parts of Alcohol; it is decomposed by boiling water.

Preparation (not official).