Nitroglycerine, Glonoin. This agent is official as Spiritus glycerylis nitratis (I % ). The previous edition called it "Glonoin," as do the homeopaths, who gave it practical introduction into therapeutics. Physicians accustomed to tablets of this volatile agent should be careful with the always active spirit. Tablets should not be depended upon unless very recently made, but coated pills retain it fairly well. I dilute the spirit with 9 parts of glycerine and have it ready for instant use hypodermically or by the mouth, and if this solution happens to be spilled it does not volatilize or the alcohol evaporate and an explosive residue remain. Tolerance to nitroglycerine is readily established, and hence the dose must be run up gradually. Merck's adonidin adequately takes its place when continuous administration establishes tolerance to glonoin.

In large doses (I or 2 I. U. S. P. spirit) it is an antispasmodic, vaso-dilating heart stimulant of primary importance in angina pectoris, acute cerebral anemia, spasmodic asthma, poisoning by carburetted hydrogen, illuminating gas, and opium poisoning with uremic symptoms.

In moderate doses (1/4 to 1/2 I. of spirit) it relieves markedly anemic headaches, many forms of heart lesions, and some functional disturbances, and in albuminuria is of considerable service.

In small doses (third or fourth dilution) it is depended upon by homeopathic physicians in congestive headaches and the pulsating headache of persons working in great heat or under artificial light. It is to be remembered that the @ is ten times the strength of the U. S. P. spirit, which corresponds to a IX dilution. The small dose is not always to be depended upon, but has distinct utility in some cases.