Properties and Uses. - Antiseptic in surgery, gynecology. It is 5 times stronger, but only one-eighth as poisonous as phenol, and one-half as poisonous as creolin. Useful in skin diseases, lupus, diphtheria, gargle for foul breath. Should be applied in aqueous solution (1-3 p. a).

Losophane. Tri-iodo-meta-cresol. -

II Aromatic Benzene Series C6h6 Closed Chain Compo 1055

Manufacture: Add aqueous solution of iodine and potassium iodide slowly, with stirring, to solution of ortho-oxyparatoluic acid in sodium bicarbonate and water, after 24 hours wash precipitate with water, crystallize from alcohol. It is in colorless, odorless needles, slightly acid, soluble in benzene, chloroform, ether, diluted NaOH, slightly in alcohol, insoluble in water, decomposed by strong caustic soda; melts at 122° C. (251° F.); contains iodine 78.39 p. c.

Properties and Uses. - Antiseptic. In parasitic skin affections, eczema, prurigo. Apply in 1-2 p. c. solutions of alcohol 3 vols, + water 1, or in 1-10 p. c. ointments of vaseline or wool-fat.

Thymolis Iodidum. Thymol Iodide. Aristol, C20H.24O2I.2. (Official.) See page 856.

Ichthyolum. Ichthyol, C28H36S3O6(NH4)2. - Ammonium-sulpho-ichthyolate, Ammonium-ichthyol-sulphonate.

Manufacture: This is a crude oil obtained by the destructive distillation of a European bituminous rock containing petrified fossil remains of fish and other animals. This oil when saturated with H2SO4 becomes heated to 100° C. (212° F.), forming ichthyol-sulphonic acid with evolution of SO2; treat now with NaOH (or NaCl) solution to remove H2SO3 and H2SO4, saturate residue with ammonia. It is a viscous, reddish-brown, syrupy liquid, bituminous odor and taste, soluble in water, glycerin, fats. Dose, gr. 10-20 (.6-1.3 Gm.), ter die.

Sodium-sulpho-ichthyolate is the most important salt for administering in pill-form, although we have the corresponding salts of lithium, zinc, and mercury. All of these are obtained by saturating the acid with the respective oxides or carbonates.

Properties and Uses. - Alterative, anodyne, discutient; chronic rheumatism, gout, lepra, eczema, urticaria, acne, intertrigo, lupus, ulcers, lymphatic enlargements, burns, frostbites, sprains, contusions, psoriasis, prostatitis. Give in pill, or apply ointment (20-50 p. c.) with wool fat.

Europhen. Di-iso-butyl-ortho-cresol-iodide.

II Aromatic Benzene Series C6h6 Closed Chain Compo 1056

Manufacture: Europhen is made like aristol, but iso-butyl-ortho-cresol is used instead of thymol. It is an amorphous golden-yellow powder, saffron-like odor, 5 times as bulky as iodoform, soluble in. alcohol, ether, chloroform, olive oil (4), insoluble in water or glycerin; melts at 110° C. (230° F.), forming a clear brown liquid; contains iodine 28 p. c. Dose, gr. 1/2-2 (.03-. 13 Gm.).

Properties and Uses. - Antiseptic, germicide, bactericide. Possesses about the same power, and used like iodoform for wounds, ulcers, burns, psoriasis, eczema, lupus, chancres, rhinitis, in ointment.

Bismuth Oxyiodogallate. Airol. -

II Aromatic Benzene Series C6h6 Closed Chain Compo 1057

Manufacture: By combining basic bismuth, oxygen, and iodine. It is a grayish-green, odorless, tasteless powder, turning red by moisture, thereby losing iodine; contains Bi2O3 44.5 p. c, iodine 24.8 p. c.

Properties and Uses. - Antiseptic; good substitute for iodoform; abscesses, burns, chancres, metritis, rhinitis, vaginitis, ulcers; in powder, ointment (10-20 p. c.) with lard, vaseline, glycerin.

Bismuth Tribromophenol, Xeroform, (C6H2Br3O)2BiOH + Bi2O3.

Manufacture: By combining chemically equal quantities of bismuth and tribromphenol. It is a yellowish-green, odorless, tasteless, insoluble powder; contains Bi2Os 50 p. c. Intestinal antiseptic; acute and chronic enteritis, burns, infected wounds, ulcers; in place of iodoform.

Antiseptin. Boro-thymol Zinc Iodide.

Manufacture: This is a mixture of zinc sulphate (85), zinc iodide (2.5), thymol (2.5), boric acid (10). Antiseptic for wounds, ulcers, etc.

8. Di-hydroxy Phenol Derivatives.

Guaiacol. Guaiacol. Guaiacolum, C7H8O2. - {Official.) See page 855.

Preparations. - 1. Guaiacolis Carbonas, (C6H4OCH3)2CO2. - (Official.) See page 856.

2. Guaiacolis Benzoas. Guaiacol Benzoate, Benzosol, Benzoyl Guaiacol, C6H4OHC6H5CO2.

Manufacture: Act on the potassium salt of guaiacol with benzoyl chloride. It is a colorless crystalline powder, odorless, tasteless, soluble in alcohol, chloroform, ether, insoluble in water; melts at 56° C. (133° F.); alcoholic solution of potassium hydroxide saponifies it, sulphuric acid turns it lemon-yellow, but ferric chloride produces no color in alcoholic solutions. Dose, gr. 5-30 (.3-2 Gm.).

3. Guaiacolis Cinnamas. Guaiacol Cinnamate, Styracol, Cinuamyl Guaiacol.

II Aromatic Benzene Series C6h6 Closed Chain Compo 1058

Manufacture: Act on guaiacol with cinnamyl-chloride by heating on water-bath, crystallize from boiling alcohol. It is in white needle crystals, soluble in ether, chloroform, insoluble in water. Dose, gr. 2-10 (.13-.6 Gm.).

4. Guaiacolis Salicylas. Guaiacol Salicylate, Guaiacol Salol.

II Aromatic Benzene Series C6h6 Closed Chain Compo 1059

Manufacture: Act on a mixture of sodium-guaiacol and sodium salicylate with phosphorus oxychloride. It is a white crystalline powder, analogous to salol, soluble in alcohol, chloroform, ether, insoluble in water. Dose, gr. 5-30 (.3-2 Gm.).