Fig. 388.' - Quinidine sulphate with KSCy: microscopic crystals.
Fig. 389. - Cinchonine sulphate with KSCy: microscopic crystals
Chinin.) Obtained by dissolving quinine sulphate (9) in water (225), + 16 p. c. sulphuric acid (10), adding to filtrate tannic acid (21) + sodium bicarbonate (3.5) dissolved in water (250), washing precipitate, drying, pulverizing. It is a pale yellow, yellowish-white, amorphous powder, odorless, tasteless, slightly bitter, astringent taste, slightly soluble in water, chloroform,ether, somewhat more so in alcohol; melts to purplish, viscous mass; contains 30-35 p. c. of anhydrous quinine, composition being somewhat varying. Tests: 1. Aqueous or alcoholic solution with ferric chloride T. S. - blue-black color. 2. Dry to constant weight - loses 10 p. c; incinerate .5 Gm. - ash .3 p. c. Impurities: Uncombined quinine, chloride, sulphate. Should be kept dark, in well-closed containers. Dose, gr. 1-10 (.06-.6 Gm.); excellent for children in diarrhoea, whooping-cough, but too insoluble as an anti-periodic - in syrup, mucilage, chocolate (quinine chocolates); troches 1 gr., +.
Quininae et Ureae Hydrochloridum, Quinine and Urea Hydrochloride, C20H24N2O2.HCl.CO(NH2)2.HCl + 5H20., official - (Syn., Quin. et Urea. Hydrochl., Quinine and Urea Chloride, Carbamidated Quinine Dihydrochloride; Fr. Chlorhydrate de Quinine et de Uree; Ger. Chinin-Harnstoff Hydrochlorid, Chininum bimuriaticum carbamida-tum.) Obtained by dissolving quinine hydrochloride (400) in diluted hydrochloric acid (800), mixing solution with urea, CO(NH2)2, (58), warming until dissolved, filtering through glass wool, crystallizing, washing crystals, drying. It is in colorless, translucent prisms, white, granular powder, odorless, very bitter taste, permanent, soluble in water (.9), alcohol (2.4); aqueous solution (1 in 20) strongly acid; contains 58 p. c. of anhydrous quinine. Tests: 1. To a cold solution of 1 Gm. in 2 Ml. (Cc.) of distilled water add 2 Ml. (Cc.) of nitric acid, cool to 0° C. (32° F.) - leaflets of urea nitrate on standing; after draining dissolve in little distilled water, + few drops of mercuric nitrate T. S. + sodium hydroxide T. S. - white precipitate. 2. Aqueous solution with silver nitrate T. S. - white precipitate, insoluble in nitric acid; incinerate 2 Gm. - ash .05 p. c. Impurities: Ammonium compounds, readily carbonizable matter. Should be kept dark, in well-closed containers. Dose, gr. 1-20 (.06-1.3 Gm.); chiefly hypo-dermically, one dose daily, in 50 p. c. solution.
Quinidina, Quinidine, C20H24N2O2. - This is fluorescent, isomeric with quinine; with chlorine or bromine water + ammonia water - emerald-green color or precipitate; precipitated from the other alkaloids by potassium iodide, but not by alkaline oxalates in neutral solution; forms numerous salts, sulphate, bisulphate, hydriodide, etc. Dose, gr. 1-30 (.06-2 Gm.).
Cinchonina, Cinchonine, C19H22N2O. - It is in white lustrous prisms or needles, odorless, at first nearly tasteless, becoming bitter, soluble in alcohol (116), water (3760), chloroform (163), ether (520), no residue, precipitated from acid solution by ammonia water by which it is dissolved sparingly, but soluble in 300 parts of ether (dif. from quinine, quinidine, cinchonidine). Dose, gr. 1-30 (.06-2 Gm.).
Cinchoninse Sulphas, Cinchonine Sulphate, (C19H22N2O)2.H2SO4 + 2H2O, official. - (Syn., Cinchonin. Sulph., Cinchoniae Sulphas; Fr. Sulfate de Cinchonine; Ger. Cinchoninum sulfuricum, Cinchonin-sulfat, Schwefelsaures Cinchonin.) It is in white, lustrous prismatic crystals, permanent, odorless, very bitter taste, soluble in water (60), hot water (33), alcohol (12.5), warm alcohol (7), chloroform (47), ether (3230); saturated aqueous solution neutral, slightly alkaline, dextrorotatory. Tests: 1. Aqueous solution (1 in 100) + barium chloride; T. S. - white precipitate, insoluble in hydrochloric acid. 2. Dry to constant weight - loses 5 p. c; incinerate 1 Gm. - ash .1 p. c; solution in diluted sulphuric acid (1 in 1000) - slight blue fluorescence. Impurities: Quinine or cinchonidine sulphate, readily carbonizable, organic substances. Should be kept dark, in well-closed containers. Dose, gr. 1-30 (.06-2 Gm.).
Figs. 390, 391. - Cinchonidine sulphate with KSCy: microscopic crystals.
Cinchonidina, Cinchonidine, C19H22N2O. - This is non-fluorescent, isomeric with cinchonine; with chlorine or bromine water + ammonia water - white color or precipitate; soluble in alcohol (20), ether (188), water (1,600), precipitated from its associated alkaloids by sodium tartrate. Dose, gr. 1-30 (.06-2 Gm.).
Cinchonidinae Sulphas, Cinchonidine Sulphate, (C19H22N2O)2.H2SO4 + 3H2O, official. - (Syn., Cinchonid. Sulph.; Fr. Sulfate de Cinchonidine (basique); Ger. Cinchonidinum sulfuricum, Cinchonidin-sulfat.) It is in white, glistening, silky needles, prisms, permanent, odorless, very bitter taste, soluble in water (65), hot water (22), alcohol (90), warm alcohol (41), chloroform (620), nearly insoluble in ether; saturated aqueous solution neutral, faintly alkaline, lsevorota-tory; when anhydrous melts at 200° C. (392° F.) with partial decomposition. Tests: 1. Aqueous solution + barium chloride T. S. - white precipitate, insoluble in hydrochloric acid. 2. Aqueous solution (1 in 80) + ammonia water - white precipitate (cinchonidine), slightly soluble in ammonia water, but when fresh soluble in ether (5), afterward separating in crystals. 3. Dry to constant weight - loses 12 p. c; incinerate 1 Gm. - ash .1 p. c; solution in diluted sulphuric acid (1 in 1000) - faint blue fluorescence. Impurities: Cinchonine or quini-dine sulphate, readily carbonizable substances. Should be kept dark, in well-closed containers. Dose, gr. 1-30 (.06-2 Gm.).