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Chemistry Of Chelation In Cancer | by Arthur Furst



This Living Chemistry Series was conceived by Editor and Publisher to advance the newer knowledge of medicine in the cause of clinical practice. In this book Dr. Furst presents the chelation basis of cancer. It is a clinical inference deduced from chemical knowledge with high probability in view of the fact that some metals cause cancer by altering enzymic activity, that many carcinogens metabolize to metal binding agents which penetrate the cell, and that most chemotherapeutic compounds inactivate by metal binding the enzymes essential for tumor growth.

TitleChemistry Of Chelation In Cancer
AuthorArthur Furst
PublisherThomas Springfield, Ill.
Year1963
Copyright1963, Thomas Springfield, Ill.
AmazonChemistry Of Chelation In Cancer
-Foreword
Our Living Chemistry Series was conceived by Editor and Publisher to advance the newer knowledge of medicine in the cause of clinical practice. The interdependence of chemistry and medicine is so grea...
-Preface
. . But, but what common property could three diverse anti leukemic drugs have in common? Logically, they might have none; each could act differently at the cellular level, and each might inhibit a ...
-Introduction. Cancer
The term cancer designates a group of diseases having similar characteristics with one outstanding common denominator, unchecked proliferation of cells. These cells, often made up predominantly of i...
-Theory Of Chelation. Complex Ions
In classical inorganic chemistry it is assumed that each metallic element can form a positive ion (cation) when one or more of the outer electrons is removed or transferred to another element. The num...
-Chelation
A chelate results from a chemical combination of an inorganic ion with at least two electron rich functional groups in a single organic molecule. This reaction results in the formation of a ring usual...
-Trace Elements And Cancer. Metals Essential In Biology
Having developed the concept of chelation, but before attempting to discuss a relationship between metals and cancer, a short general review of the elements found in nature may be in order. A numbe...
-Metal Carcinogenesis
That certain elements in the free or combined state can be primary causative agents for human cancer has been known for many years. However, in a review of metal carcinogenesis, it is essential to con...
-Metals Associated With Tissues, Normal And Diseased
The proclivity of normal tissues for various metals may also shed some fight on the carcinogenic process. Studies on the distributions and concentrations of trace elements in human tissues and especia...
-Metals Associated With Neoplastic Tissue
In addition to the phenomenon of metal carcinogenesis, there is accumulating information concerning the nature and relative amounts of metal ions associated with cancer tissue in humans as well as exp...
-Trace Metals In Plants And Soils
Where do most of the trace metals found in tissues come from? Since the answer relates to the food ingested, the focus turns to the edible plants, and then, ultimately, to the soil. The origin of thes...
-Relationship Between Geology And Health
It has long been known that in a certain region of the United States a goiter belt exists. The incidence of goiter formation correlates inversely as the concentration of iodine in the soil. In areas o...
-Carcinogenic Compounds And Chelating Agents
A large variety of chemicals are implicated as causative agents for cancer. At the present state of knowledge there is no evidence that the original agent applied is itself the primary carcinogen; a m...
-Polycyclic Aromatic Hydrocarbons and Cholesterol
Polycyclic Aromatic Hydrocarbons Early observations linked polycyclic aromatic hydrocarbons with occupational and experimental cancer. Now, di benzo(a, J)pyrene should be further investigated as on...
-Azo Dyes
The most extensive studies of azo dye carcinogenesis were made on agents that produce tumors distant from the site of application. Thus hepatomas were obtained by adding certain dyes to the diet. It i...
-Aromatic Amines
Two aromatic rings are not essential for carcinogenicity, but it is doubtful if unsubstituted aniline is a carcinogen, at least for rabbits and guinea pigs. A derivative, however, o-toluidine, has bee...
-Biotransformations Of Tryptophan
Very recently, during the continuing study of the metabolism of acetaminofluorene, it was found that N-hydroxylation was a major metabolic pathway, and thus a new chelating metabolite was isolated. It...
-Cancer Chemotherapeutic Agents
A considerable number of diverse agents have been tested for anticancer activity, and many have some retarding effect on growth of both human and experimental neoplasms. These effects, unfortunately, ...
-Folic Acid Antagonists
The forerunner of the folic acid antagonists was an L. casei factor which caused the regression of spontaneous breast tumor in mice. Later the factor was found to be pteroyl triglu-tamic acid. Folic a...
-Purines As Anti-Cancer Drugs
Since the introduction of 8-azaguanine and the study of its mode of action as well as its clinical effectiveness, many purines have been introduced for human cancer chemotherapy. Most of these purines...
-Pyrimidines And Triazines
Only a few of the substituted pyrimidines reported to be active as chemotherapeutic agents seem to fit the chelate hypothesis. It should also be noted that only a few of the pyrimidines have been foun...
-Natural Products
The structures of many of the natural products found active against tumors have not been elucidated. These include many plant extracts, such as alkaloids from Vinca rosea Linn, the periwinkle plant, w...
-Salts And Preformed Chelates
Relatively speaking, not many inorganic salts have been tried as potential cancer chemotherapeutic agents. Some thirty-three metallic chlorides were evaluated both for their effect on chick embryos an...
-Miscellaneous Carcinostatic Compounds. Styrylquinolines
Styrylquinolines, perhaps among the newest anticancer agents, are not easily placed in any classification. These compounds are more precisely derivatives of p-( dimethyl-ammo )-4-quinolyl styrene (LXX...
-Carcinogenic Agents For Tumor Control
It is almost more difficult to explain the tumor inhibition properties of hydrocarbons than it is to explain their carcinogenic function. Benzanthracene does inhibit tumor growth in rodents, but this ...
-Trace Metals And Biological Function
The role of trace metals in the biological processes has by no means been clearly elucidated. Various postulates are being presented to account for the catalytic activity of some metals and unusual to...
-The Enzymes
Functions of these trace elements and their relationships to enzymes are being extensively studied (92,268, 342, 560,612). More and more enzymes are being found to be metal-dependent or metal-containi...
-The Nucleic Acids
In the final analysis, some explanation must be given for any interaction of metals and nucleic acids. Do these elements serve any specific purpose-or is this association an artifact of experimentatio...
-Speculations And Conclusions. Properties Of Chelating Agents
Before intelligent predictions can be made about the mode of action of chelating agents in the carcinogenic process or the design of specific chelating agents which may have anti-tumor properties, mor...
-The Enzyme Cancer Problem
Data from model metal-dependent enzyme systems may shed light on the metal-cancer problem. Since metals can displace one another in enzyme systems, there are a variety of ways in which the action of a...
-Nucleic Acids And Cancer
Speculations on the effects of abnormal trace metals or chelating agents on the nucleic acids lead to the conclusion that both structure and function of the genetic material may be altered. This aberr...
-Carcinogenesis. Metals. Chelating Agents
Metals must act intracellularly if any interaction or equilibration with nucleic acids or enzymes is to take place. Carcinogens too must exert their influence on a cellular level. Most carcinogenic hy...
-Metal and Chemical Carcinogenesis
Metal Carcinogenesis Metals can be carcinogenic if their local cellular concentration becomes sufficiently high so that they can compete with the normal metals for the available binding site in the...
-Other Chelating Agents
Hormones Hormones may alter the permeability of the cell wall and allow the entrance of cations in greater concentration. Free Radicals And X-Rays It is not possible to give a clear picture o...
-Predictions And Design Of New Anticancer Compounds
Is it a coincidence that a large number, if not most, of the anticancer agents reported have chelating ability as a common property? If this is fundamental to the cancer problem, it should be possible...







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previous page: Progress Against Cancer | by The National Advisory Cancer Council
  
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next page: Cancer Manual For Public Health Nurses | by The National Cancer Institute